The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design

Autor: Hyke G. H. Tamminga, Hilde M. Geurts, Cheima Bouziane, Marco A. Bottelier, Michiel B. de Ruiter, R.M. Rijsman, Anne Klomp, Anouk Schrantee, Damiaan Denys, M.L.J. Schouw, Hans Reitsma, Liesbeth Reneman, Henricus G. Ruhé, Ramón J. L. Lindauer, Frits Boer
Přispěvatelé: Other departments, Radiology and Nuclear Medicine, ANS - Amsterdam Neuroscience, Child Psychiatry, Adult Psychiatry, APH - Amsterdam Public Health, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Netherlands Institute for Neuroscience (NIN), Brein en Cognitie (Psychologie, FMG), Faculteit der Geneeskunde
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
RESTLESS LEGS SYNDROME
FUNCTIONAL MAGNETIC-RESONANCE
CHRONIC FLUOXETINE TREATMENT
ORAL METHYLPHENIDATE
Study Protocol
DEFICIT-HYPERACTIVITY DISORDER
Child
Problem Solving
MAJOR DEPRESSIVE DISORDER
Methylphenidate
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
Neuropsychology
Brain
Antidepressants
Anxiety Disorders
Antidepressive Agents
Psychiatry and Mental health
Research Design
Major depressive disorder
Anxiety
Female
medicine.symptom
Psychology
medicine.drug
Clinical psychology
ADOLESCENT DEPRESSION
Adult
medicine.medical_specialty
Adolescent
Development
Placebo
Young Adult
Double-Blind Method
Fluoxetine
mental disorders
medicine
Animals
Humans
Attention deficit hyperactivity disorder
Psychiatry
Depressive Disorder
medicine.disease
Clinical trial
Cross-Sectional Studies
PSYCHOMETRIC PROPERTIES
Attention Deficit Disorder with Hyperactivity
GLOBAL ASSESSMENT SCALE
Central Nervous System Stimulants
Psychostimulants
Zdroj: BMC psychiatry, 14(1). BioMed Central
BMC Psychiatry, 14:48. BMC
BMC Psychiatry, 14. BioMed Central
BMC Psychiatry, 14:48. BioMed Central
BMC Psychiatry
ISSN: 1471-244X
Popis: Background Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans. Methods/Design Animal studies were carried out to investigate age-related effects of psychotropic drugs and to validate new neuroimaging techniques. In addition, we set up two double-blind placebo controlled clinical trials with MPH in 50 boys (10–12 years) and 50 young men (23–40 years) suffering from ADHD (ePOD-MPH) and with FLX in 40 girls (12–14 years) and 40 young women (23–40 years) suffering from depression and anxiety disorders (ePOD-SSRI). Trial registration numbers are: Nederlands Trial Register NTR3103 and NTR2111. A cross-sectional cohort study on age-related effects of these psychotropic medications in patients who have been treated previously with MPH or FLX (ePOD-Pharmo) is also ongoing. The effects of psychotropic drugs on the developing brain are studied using neuroimaging techniques together with neuropsychological and psychiatric assessments of cognition, behavior and emotion. All assessments take place before, during (only in case of MPH) and after chronic treatment. Discussion The combined results of these approaches will provide new insight into the modulating effect of MPH and FLX on brain development.
Databáze: OpenAIRE
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