The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design
Autor: | Hyke G. H. Tamminga, Hilde M. Geurts, Cheima Bouziane, Marco A. Bottelier, Michiel B. de Ruiter, R.M. Rijsman, Anne Klomp, Anouk Schrantee, Damiaan Denys, M.L.J. Schouw, Hans Reitsma, Liesbeth Reneman, Henricus G. Ruhé, Ramón J. L. Lindauer, Frits Boer |
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Přispěvatelé: | Other departments, Radiology and Nuclear Medicine, ANS - Amsterdam Neuroscience, Child Psychiatry, Adult Psychiatry, APH - Amsterdam Public Health, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Netherlands Institute for Neuroscience (NIN), Brein en Cognitie (Psychologie, FMG), Faculteit der Geneeskunde |
Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
RESTLESS LEGS SYNDROME FUNCTIONAL MAGNETIC-RESONANCE CHRONIC FLUOXETINE TREATMENT ORAL METHYLPHENIDATE Study Protocol DEFICIT-HYPERACTIVITY DISORDER Child Problem Solving MAJOR DEPRESSIVE DISORDER Methylphenidate ATTENTION-DEFICIT/HYPERACTIVITY DISORDER Neuropsychology Brain Antidepressants Anxiety Disorders Antidepressive Agents Psychiatry and Mental health Research Design Major depressive disorder Anxiety Female medicine.symptom Psychology medicine.drug Clinical psychology ADOLESCENT DEPRESSION Adult medicine.medical_specialty Adolescent Development Placebo Young Adult Double-Blind Method Fluoxetine mental disorders medicine Animals Humans Attention deficit hyperactivity disorder Psychiatry Depressive Disorder medicine.disease Clinical trial Cross-Sectional Studies PSYCHOMETRIC PROPERTIES Attention Deficit Disorder with Hyperactivity GLOBAL ASSESSMENT SCALE Central Nervous System Stimulants Psychostimulants |
Zdroj: | BMC psychiatry, 14(1). BioMed Central BMC Psychiatry, 14:48. BMC BMC Psychiatry, 14. BioMed Central BMC Psychiatry, 14:48. BioMed Central BMC Psychiatry |
ISSN: | 1471-244X |
Popis: | Background Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans. Methods/Design Animal studies were carried out to investigate age-related effects of psychotropic drugs and to validate new neuroimaging techniques. In addition, we set up two double-blind placebo controlled clinical trials with MPH in 50 boys (10–12 years) and 50 young men (23–40 years) suffering from ADHD (ePOD-MPH) and with FLX in 40 girls (12–14 years) and 40 young women (23–40 years) suffering from depression and anxiety disorders (ePOD-SSRI). Trial registration numbers are: Nederlands Trial Register NTR3103 and NTR2111. A cross-sectional cohort study on age-related effects of these psychotropic medications in patients who have been treated previously with MPH or FLX (ePOD-Pharmo) is also ongoing. The effects of psychotropic drugs on the developing brain are studied using neuroimaging techniques together with neuropsychological and psychiatric assessments of cognition, behavior and emotion. All assessments take place before, during (only in case of MPH) and after chronic treatment. Discussion The combined results of these approaches will provide new insight into the modulating effect of MPH and FLX on brain development. |
Databáze: | OpenAIRE |
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