Thyroid dysfunction in laryngectomees—10 years after treatment
| Autor: | Ambrose Chung-Wai Ho, William I. Wei, Anthony Po Wing Yuen, Paul K.Y. Lam, Wai-Kuen Ho |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases medicine.medical_treatment Antineoplastic Agents Laryngectomy Gastroenterology Hypothyroidism Risk Factors Internal medicine medicine Carcinoma Humans Laryngeal Neoplasms Aged Retrospective Studies Subclinical infection business.industry Incidence (epidemiology) Thyroid Retrospective cohort study medicine.disease Surgery medicine.anatomical_structure Otorhinolaryngology Chemotherapy Adjuvant Relative risk Multivariate Analysis Thyroidectomy Female Radiotherapy Adjuvant Cisplatin Thyroid function business Follow-Up Studies |
| Zdroj: | Head & Neck. 30:336-340 |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.20693 |
| Popis: | Background. Hypothyroidism is 1 of the complications that follow treatment of various head and neck cancers. In the lit- erature, reviews using different primary sites and differences in treatment modalities make comparison of post-treatment hypo- thyroidism not possible. The objective of this study was to evalu- ate the incidence of hypothyroidism in a homogenous group of patients who were treated with total laryngectomy and irradiation for laryngeal carcinoma and to assess the importance of differ- ent variables in the occurrence of hypothyroidism. Methods. A retrospective review of 147 total laryngectomy patients between 1993 and 2003 was carried out. Serum thyro- xine level and free T4 levels were assessed in all patients. Hypo- thyroidism was classified as subclinical (increased thyroid-stimu- lating hormone and normal free T4 levels) and clinical (increased thyroid-stimulating hormone and decreased free T4 levels). Results. The results showed that the overall incidence of hypo- thyroidism was 49% (44% subclinical and 5% clinical). Hemithy- roidectomy and advanced tumor staging were risk factors for the development of hypothyroidism in these patients (p < .05) with a relative risk of 2.1 (CI 95%, 1.4-3.1) and 1.3 (CI 95%, 1.1-1.6), respectively. During follow-up, 19.9% of patients developed hypothyroidism at 3 years, 38.6% at 6 years; at 10 year follow-up, 93.3% of them had hypothyroidism. Conclusions. In conclusion, hypothyroidism is a frequent com- plication in patients treated with radiotherapy and total laryngec- tomy for laryngeal cancer, especially when treatment includes hemithyroidectomy. These patients should have their thyroid function evaluated periodically even 10 years after treatment. V V C 2007 Wiley Periodicals, Inc. Head Neck 30: 336-340, 2008 |
| Databáze: | OpenAIRE |
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