Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats
| Autor: | Babacar Faye, N.A. Mbodj, Gata Yoro Sy, Nongonierma Rb, Cisse A, M. Sarr |
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| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Drug Evaluation Preclinical Administration Oral Vernonia colorata Carbohydrate metabolism Pharmacognosy law.invention Diabetes Mellitus Experimental Glibenclamide Acetone chemistry.chemical_compound law Alloxan Diabetes mellitus Drug Discovery Glyburide Medicine Animals Hexanes Rats Wistar Medicine African Traditional Pharmacology Glucose tolerance test Traditional medicine medicine.diagnostic_test business.industry Plant Extracts Glucose Tolerance Test medicine.disease Hypoglycemia Rats Plant Leaves Disease Models Animal Glucose chemistry business Phytotherapy Vernonia medicine.drug |
| Zdroj: | Journal of ethnopharmacology. 98(1-2) |
| ISSN: | 0378-8741 |
| Popis: | The aqueous extract of Vernonia colorata (Willd.) Drake (Composeae) leaves is used by African traditional medicine practitioners as a remedy for the treatment of diabetes. Our previous studies have shown the hypoglycaemic activity of the aqueous extract of Vernonia colorata leaves (300 mg/kg, per os) in normoglycaemic rats. The aim of the present study was to investigate the hypoglycaemic and antidiabetic activity of acetonic and hexanic extracts of the leaves of Vernonia colorata in order to further discriminate the type of extract which provides a better antidiabetic activity. Experiments were performed in normoglycaemic and alloxan-induced diabetic rats. The acetonic extract of the leaves of Vernonia colorata (AELVC) (100 mg/kg, per os) induced a significant decrease of blood glucose in normoglycaemic rats. The glycaemia varied from 4.72+/-0.11 to 3.72+/-0.22 mmol/l (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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