THYROID NODULE LOCATION ON ULTRASONOGRAPHY AS A PREDICTOR OF MALIGNANCY
| Autor: | Sibai Zakaria, Fan Zhang, Oluwaseun Oluwo, Tooraj Zahedi, Matthew Castillo, Fady Farag, Priyadarshini Gangula, Fiorella Castillo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Thyroid nodules
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Biopsy Fine-Needle 030209 endocrinology & metabolism Malignancy 03 medical and health sciences 0302 clinical medicine Endocrinology Biopsy Medicine Humans 030212 general & internal medicine Thyroid Neoplasms Thyroid Nodule Retrospective Studies Ultrasonography medicine.diagnostic_test business.industry Thyroid Nodule (medicine) Retrospective cohort study General Medicine medicine.disease medicine.anatomical_structure Female Radiology medicine.symptom business |
| Zdroj: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 25(2) |
| ISSN: | 1530-891X |
| Popis: | The diagnostic capacity of ultrasonography (US) for differentiating between malignant and benign thyroid nodules is crucial in preventing unnecessary invasive procedures. This is the first study to evaluate whether thyroid nodule location on US has predictive value for malignancy.We retrospectively reviewed data from 219 patients with thyroid nodules who underwent fine-needle aspiration biopsy in 1 year. Patients' demographics as well as nodule's laterality, polarity, morphology, and multinodularity were analyzed. All malignant lesions were confirmed by surgical pathology.The majority of the patients were female (86.2%). Nodules were evenly distributed between the right lobe (46.3%) and left lobe (49.5%). Eight nodules (4.2%) were located in the isthmus. Most nodules (79.3%) were located in the lower pole, while 9.6% were located in the upper pole and 6.9% in the middle pole. Seventy-five patients (39.9%) had multiple nodules. Fourteen nodules were malignant, representing a prevalence of 7.4%. A significantly higher frequency of malignancy was observed in upper pole (22.2%) compared to lower pole (4.7%) and middle pole (15.4%). A multiple logistic regression model confirmed such association after adjusting for age, body mass index, multinodularity, and laterality. The odds of malignancy in the upper pole were 4 times higher than other locations (odds ratio, 4.6; P = .03).Our study is the first showing that thyroid nodules located in the upper pole can be considered as having higher risk for malignancy. It may enhance the predictive value of malignancy if it is included in thyroid nodule ultrasound classification guidelines.AACE = American Association of Clinical Endocrinologists; ATA = American Thyroid Association; BMI = body mass index; FNA = fine-needle aspiration; TMS = total malignancy score; TTW = taller than wide; US = ultrasonography. |
| Databáze: | OpenAIRE |
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