Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver disease (NAFLD) -- preliminary findings
| Autor: | Bruno Zilberstein, Maria do Socorro Bastos, Alfredo Halpern, Joel Faintuch, Bianca Ishimoto Della Nina, Carlos K. Furuya, Alessandra Rascovski, Denise P. Vezozzo, Katia Yahnosi, Joaquim Gama-Rodrigues, Dulcineia S P Abdala, Flair José Carrilho, Mitsunori Matsuda, Arthur B. Garrido, Claudia P. Oliveira, Venancio Avancini Ferreira Alves |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis Endocrinology Diabetes and Metabolism Gastric Bypass medicine.disease_cause Gastroenterology Risk Assessment Severity of Illness Index Statistics Nonparametric Body Mass Index Intraoperative Period Internal medicine Nonalcoholic fatty liver disease medicine Humans Prospective Studies Probability Analysis of Variance Nutrition and Dietetics Chi-Square Distribution medicine.diagnostic_test business.industry Fatty liver Biopsy Needle Anastomosis Roux-en-Y medicine.disease Immunohistochemistry Obesity Morbid Fatty Liver Oxidative Stress Cross-Sectional Studies Treatment Outcome Liver biopsy Surgery Female Lipid Peroxidation Steatosis Metabolic syndrome Steatohepatitis business Oxidative stress Follow-Up Studies |
| Zdroj: | Obesity surgery. 15(4) |
| ISSN: | 0960-8923 |
| Popis: | Background: Pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains incompletely known, and oxidative stress is one of the mechanisms incriminated. The aim of this study was to evaluate the role of liver oxidative stress in NAFLD affecting morbidly obese patients. Methods: 39 consecutive patients with BMI >40 kg/m2 submitted to Roux-en-Y gastric bypass were enrolled, and wedge liver biopsy was obtained during operation. Oxidative stress was measured by concentration of hydroperoxides (CEOOH) in liver tissue. Results: Female gender was dominant (89.7%) and median age was 43.6 ± 11.1 years. Histology showed fatty liver in 92.3%, including 43.6% with nonalcoholic steatohepatitis (NASH), 48.7% with isolated steatosis and just 7.7% with normal liver. Liver cirrhosis was present in 11.7% of those with nonalcoholic steatohepatitis. Concentration of CEOOH was increased in the liver of patients with NASH when compared to isolated steatosis and normal liver (0.26± 0.17, 0.20± 0.01 and 0.14± 0.00 nmol/mg protein, respectively) (P |
| Databáze: | OpenAIRE |
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