The Role of Magnetic Resonance Imaging in Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus: Analyzing MOCART 1 and 2.0
| Autor: | Christoph Germann, Lizzy Weigelt, Jakob Ackermann, Arnd F. Viehöfer, Stephan H. Wirth, Fabio A. Casari |
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| Přispěvatelé: | University of Zurich, Ackermann, Jakob |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biomedical Engineering
2204 Biomedical Engineering Physical Therapy Sports Therapy and Rehabilitation 610 Medicine & health Osteoarthritis Transplantation Autologous Talus Cohort Studies medicine Immunology and Allergy Postoperative outcome Humans 3612 Physical Therapy Sports Therapy and Rehabilitation Cartilage repair Clinical Research papers medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Autologous matrix-induced chondrogenesis 2723 Immunology and Allergy 10046 Balgrist University Hospital Swiss Spinal Cord Injury Center business Nuclear medicine Chondrogenesis |
| Zdroj: | Cartilage |
| Popis: | Objective To determine the role of magnetic resonance imaging (MRI) MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 1 and 2.0 scores in the assessment of postoperative outcome after autologous matrix-induced chondrogenesis (AMIC) for the treatment of osteochondral lesions of the talus (OLTs). It was hypothesized that preoperative patient factors or OLT morphology are associated with postoperative MOCART scores; yet postoperative clinical outcome is not. Study Design Cohort study; Level of evidence, 4. This study evaluated isolated AMIC that were implanted on the talus of 35 patients for the treatment of symptomatic OLT. Tegner and AOFAS (American Orthopaedic Foot and Ankle Society) scores were obtained at an average follow-up of 4.5 ± 1.8 years and postoperative MRI scored according to the MOCART 1 and 2.0. Results OLT size showed significant correlation with postoperative MRI scores (MOCART 1: P = 0.006; MOCART 2.0: P = 0.004). Bone grafting was significantly associated with a MOCART 1 subscale (signal intensity of repair tissue; P = 0.038). Age and defect size showed significant correlations with MOCART 2.0 subscales ( P < 0.05). Patients with shorter follow-up had a significantly higher MOCART 1 score and a trend toward better MOCART 2.0 scores than patients with longer follow-up (64.7 vs. 52.9 months, P = 0.02; 69.4 vs. 60.6 months, P = 0.058). No MOCART score was associated with postoperative patient-reported outcomes (n.s.). Conclusion Osteochondral lesion size is associated with postoperative MOCART scores in patients treated with AMIC for OLTs, with decreasing MOCART scores over time. Yet clinical outcome does not correlate with any MOCART score. Thus, MOCART assessment seems to have no significant role in the postoperative treatment of asymptomatic patients that underwent AMIC for OLTs. |
| Databáze: | OpenAIRE |
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