A case of chronic hepatitis C with nephrotic diabetic nephropathy who achieved sustained viral remission by double-filtration plasmapheresis and interferon combination therapy
| Autor: | Hideki Yamaya, Syogo Kimura, Masaru Nakagawa, Hitoshi Yokoyama, Junko Imura, Keiji Fujimoto, Hiroshi Okuyama, Yoshihiro Chikazawa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Combination therapy medicine.medical_treatment Gastroenterology Antiviral Agents Polyethylene Glycols Diabetic nephropathy Internal medicine Ribavirin Internal Medicine medicine Humans Diabetic Nephropathies Aged Hepatitis business.industry Remission Induction Interferon-alpha General Medicine Hepatitis C Plasmapheresis Hepatitis C Chronic Viral Load medicine.disease Cryoglobulinemia Combined Modality Therapy Recombinant Proteins Immunology business Viral load Nephrotic syndrome |
| Zdroj: | Internal medicine (Tokyo, Japan). 51(15) |
| ISSN: | 1349-7235 |
| Popis: | We report a 66-year-old man with chronic hepatitis caused by hepatitis type C virus of genotype-1b and high-viral-load combined with cryoglobulinemia and advanced diabetic nephropathy in whom we successfully achieved viral removal and eradication by DFPP (VRAD). The dose of PEG-interferon was reduced to 70 mg/week due to thrombocytopenia. Rivavirin was discontinued at day 21 due to anemia. Even with treatment of PEG-interferon alone, the condition was judged to be sustained viral remission at the end of the observation. This is a successful report of VRAD in a combined case of diabetic and HCV-related cryoglobulin-nephropathy with nephrotic syndrome. The therapeutic effect of IFN seemed to be efficiently enhanced by concomitant DFPP (VRAD therapy). |
| Databáze: | OpenAIRE |
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