The pharmacokinetics of meropenem in volunteers
| Autor: | D. M. Wilkinson, W Bastain, A. Featherstone, M Hutchison, S. J. Haworth, R P Bax |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Microbiology (medical)
Adult Male Abdominal pain medicine.drug_class Urinary system Antibiotics Pharmacology Meropenem Pharmacokinetics Reference Values polycyclic compounds medicine Humans Pharmacology (medical) Drug Interactions Volunteer Chromatography High Pressure Liquid business.industry Probenecid Half-life biochemical phenomena metabolism and nutrition bacterial infections and mycoses Infectious Diseases Carbapenems Anesthesia Thienamycins medicine.symptom business medicine.drug Half-Life |
| Zdroj: | The Journal of antimicrobial chemotherapy. 24 |
| ISSN: | 0305-7453 |
| Popis: | Two human volunteer studies were performed with meropenem: a dose proportionality study of 0.25, 0.5 and 1.0 g and a probenecid interaction study. Six volunteers took part in each study. Meropenem was generally well tolerated: One volunteer was withdrawn from the dose proportionality study because of looseness of stool and abdominal pain after a dose of 1.0 g. The plasma concentrations of meropenem were linearly related to dose. The half-life of meropenem was approximately 1 h and the urinary recovery of unchanged drug was 79%. In the presence of probenecid the plasma half-life of meropenem was increased by 33% but the urinary recovery was unaffected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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