Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells
| Autor: | Laurent Boucontet, Ana Cumano, Odile Burlen-Defranoux, Paulo Vieira, Helene C. Dujardin, Antonio Bandeira |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
T cell Spleen chemical and pharmacologic phenomena Biology Interleukin 21 Mice Antigens CD T-Lymphocyte Subsets medicine Splenocyte Animals IL-2 receptor RNA Messenger Autoimmune disease Mice Knockout Mice Inbred BALB C Multidisciplinary FOXP3 Gene Expression Regulation Developmental hemic and immune systems Forkhead Transcription Factors Receptors Interleukin-2 Biological Sciences medicine.disease Thymectomy DNA-Binding Proteins medicine.anatomical_structure Animals Newborn Immunology Integrin alpha Chains Homeostasis |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 101(40) |
| ISSN: | 0027-8424 |
| Popis: | Thymectomy at day 3 after birth leads to autoimmune disease in some genetic backgrounds. Disease is thought to be caused by the lack/paucity of regulatory T cells. We show that 3-day-old mice already contain a significant compartment ofFoxp3-expressing CD25+CD4+splenocytes. Whereas, in adult spleen, the subsets of regulatory T cells (CD25+and/or CD103+) express high amounts ofFoxp3mRNA, in 3-day-old mice, both thymic and splenic CD25+CD4+T cell subsets express lower amounts ofFoxp3mRNA, and CD103+cells are barely detected. In adult day 3-thymectomized mice, the CD25+CD4+T cell subset is overrepresented (most of the cells being CD103+) and expresses high amounts ofFoxp3mRNA, independent of the development of autoimmune gastritis. These cells control inflammatory bowel disease and the homeostatic expansion of lymphocytes. This study demonstrates that the peripheral immune system of newborn mice is endowed of a remarkable regulatory potential, which develops considerably in the absence of thymic supply. |
| Databáze: | OpenAIRE |
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