Identification of novel in vitro antibacterial action of cloprostenol and evaluation of other non-antibiotics against multi-drug resistant A. baumannii
| Autor: | Mark D. P. Willcox, Aqeel Shahzad, Shakeel Shahzad |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Acinetobacter baumannii medicine.drug_class Klebsiella pneumoniae 030106 microbiology Antibiotics Microbial Sensitivity Tests medicine.disease_cause 01 natural sciences Microbiology 03 medical and health sciences Drug Resistance Multiple Bacterial Drug Discovery medicine Escherichia coli Humans Pharmacology biology Strain (chemistry) 010405 organic chemistry Chemistry Cloprostenol biology.organism_classification Antimicrobial In vitro 0104 chemical sciences Anti-Bacterial Agents Drug Therapy Combination Antibacterial activity Acinetobacter Infections |
| Zdroj: | The Journal of antibiotics. 73(1) |
| ISSN: | 1881-1469 |
| Popis: | A total of 24 non-antibiotic compounds were tested for their antimicrobial activity against Escherichia coli, Klebsiella pneumoniae (ATCC) and an MDR strain of Acinetobacter baumannii using an agar well diffusion assay. To study additive effects, 100 µl of each antibiotic and 50 µl of each non-antibiotic were used. Cloprostenol was the only non-antibiotic that showed antibacterial activity against all bacterial strains. Cloprostenol had an additive antimicrobial effect with the tested antibiotics against the MDR A. baumannii strain. |
| Databáze: | OpenAIRE |
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