Computational investigation of blood flow and flow-mediated transport in arterial thrombus neighborhood
| Autor: | Chayut Teeraratkul, Shawn C. Shadden, Debanjan Mukherjee, Zachariah Irwin |
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| Rok vydání: | 2021 |
| Předmět: |
Computer science
Finite Element Analysis 0206 medical engineering Pulsatile flow Hemodynamics 02 engineering and technology Lyapunov exponent symbols.namesake Pressure medicine Humans Computer Simulation cardiovascular diseases Thrombus Stroke Pressure gradient Mechanical Engineering Models Cardiovascular Thrombosis Large artery Arteries Mechanics Blood flow medicine.disease 020601 biomedical engineering Flow (mathematics) Regional Blood Flow Modeling and Simulation Arterial thrombus cardiovascular system symbols Blood Flow Velocity Geology Biotechnology |
| Zdroj: | Biomechanics and Modeling in Mechanobiology. 20:701-715 |
| ISSN: | 1617-7940 1617-7959 |
| Popis: | A pathologically formed blood clot or thrombus is central to major cardiovascular diseases like heart attack and stroke. Detailed quantitative evaluation of flow and flow-mediated transport processes in the thrombus neighborhood within large artery hemodynamics is crucial for understanding disease progression and assessing treatment efficacy. This, however, remains a challenging task owing to the complexity of pulsatile viscous flow interactions with arbitrary shape and heterogeneous microstructure of realistic thrombi. Here, we address this challenge by conducting a systematic parametric simulation based study on characterizing unsteady hemodynamics and flow-mediated transport in the neighborhood of an arterial thrombus. We use a hybrid particle-continuum based finite element approach to handle arbitrary thrombus shape and microstructural variations. Results from a cohort of 50 different unsteady flow scenarios are presented, including unsteady vortical structures, pressure-gradient across the thrombus boundary, finite time Lyapunov exponents, and dynamic coherent structures that organize advective transport. We clearly illustrate the combined influence of three key parameters - thrombus shape, microstructure, and extent of wall disease - in terms of: (a) determining hemodynamic features in the thrombus neighborhood; and (b) governing the balance between advection, permeation, and diffusion to regulate transport processes in the thrombus neighborhood. |
| Databáze: | OpenAIRE |
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