Clinical importance of serum CEA and CA-19-9 levels in oesophagogastric junction adenocarcinomas
| Autor: | Selçuk Gülmez, Tolga Olmez, Ozlem Zeliha Sert, Emre Aray, Erdal Polat, Mustafa Duman, Orhan Uzun, Hilmi Bozkurt, Aziz Serkan Senger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lymphovascular invasion medicine.medical_treatment tumour markers Gastroenterology survival Carcinoembryonic antigen Internal medicine Diabetes mellitus Medicine Original Paper Chemotherapy adenocarcinoma biology business.industry Incidence (epidemiology) medicine.disease Log-rank test oesophagogastric junction biology.protein Adenocarcinoma CA19-9 prognosis business |
| Zdroj: | Gastroenterology Review, Vol 16, Iss 3, Pp 240-247 (2020) Przegla̜d Gastroenterologiczny |
| ISSN: | 1897-4317 1895-5770 |
| Popis: | Introduction In recent years, the incidence of gastroesophageal junction tumors has increased rapidly in worldwide. Aim To evaluate pretreatment serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in oesophagogastric junction (OGJ) adenocarcinomas regarding clinicopathologic characteristics and overall survival. Material and methods Patients undergoing curative surgery diagnosed with OGJ adenocarcinoma in the gastrointestinal surgery clinic between 2007 and 2019 were included in the study retrospectively. Kaplan Meier and Log Rank tests were performed in survival analyses. Logistic regression analysis was performed to state the independent variables affecting survival. Results The mean age of the 70 patients included in the study was 59.78 ±10.49 (31-76) years. Serum CEA and CA 19-9 were high in 19 (27.1%) patients. CEA ≥ 5 ng/ml was found to be statistically significant in patients receiving neoadjuvant chemotherapy (NAC) and in patients with a high number of positive lymph nodes (N +) (p = 0.041 and p = 0.042, respectively). CA 19-9 positivity was statistically higher in patients with lymphovascular invasion (LVI) and diabetes mellitus (DM) (p = 0.042 and p = 0.012, respectively). The age and N+ findings of the patients in the CA 19-9-positive group were statistically significant compared to the patients in the CA 19-9-negative group (p = 0.039 and p = 0.007, respectively). Overall survival rates of 1-3 and 5 years were statistically significantly lower in patients who were CA 19-9 positive (p = 0.016). For patients in whom both tumour markers were positive, the N+ mean value was statistically significantly higher (p = 0.001). Conclusions In our study, a significant relationship was found in terms of overall survival and serum CA 19-9 in OGJ adenocarcinoma, and it was associated with both tumour markers being positive and the mean N+ value. |
| Databáze: | OpenAIRE |
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