von Willebrand factor activity levels are influenced by driver mutation status in polycythemia vera and essential thrombocythemia patients with well-controlled platelet counts

Autor:	Kazuhide Iizuka, Soji Morishita, Yuji Nishizaki, Yoshikazu Iizuka, Noriyoshi Iriyama, Tomonori Ochiai, Naotake Yanagisawa, Hajime Yasuda, Jun Ando, Akihiko Gotoh, Masami Takei, Yoshihiro Hatta, Hideki Nakamura, Tomohiro Nakayama, Norio Komatsu
Rok vydání:	2022
Předmět:	Platelet Count von Willebrand Factor Mutation Humans Hematology General Medicine Janus Kinase 2 Calreticulin Polycythemia Vera Thrombocythemia Essential
Zdroj:	European journal of haematologyREFERENCES. 109(6)
ISSN:	1600-0609
Popis:	von Willebrand factor ristocetin cofactor (vWF activity) and platelet count (PLT) are negatively correlated in patients with polycythemia vera (PV) and essential thrombocythemia (ET). However, vWF activity does not always normalize upon controlling PLT in those patients. To address this issue, we investigated the correlation between vWF activity and PLT in PV and ET patients. The negative correlation between vWF activity and PLT was stronger in calreticulin mutation-positive (CALR+) ET than in Janus kinase 2 mutation-positive (JAK2+) PV or ET groups. When PLT were maintained at a certain level (600 × 10
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db785244ced1c078a41fe0f4bd292d70 https://pubmed.ncbi.nlm.nih.gov/36130908 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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