Seroprevalence of human herpesvirus 8 infection in children born to HIV-1- infected women in São Paulo, Brazil

Autor: Maria Isabel de Moraes-Pinto, L M Sumita, Cláudio Sérgio Pannuti, Daisy Maria Machado, Regina Célia de Menezes Succi, Vanda Akico Ueda Fick de Souza
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Male
Pediatrics
Physiology
Cross-sectional study
Seroprevalence
HIV Infections
HIV Antibodies
Biochemistry
Pregnancy
Outpatient clinic
Pregnancy Complications
Infectious
General Pharmacology
Toxicology and Pharmaceutics
Child
Prospective cohort study
Children
lcsh:QH301-705.5
education.field_of_study
lcsh:R5-920
General Neuroscience
virus diseases
Herpesviridae Infections
General Medicine
LANA-IFA
AIDS
Fluorescent Antibody Technique
Direct
Child
Preschool
Herpesvirus 8
Human
Female
lcsh:Medicine (General)
Brazil
Cohort study
medicine.medical_specialty
Sexual transmission
Adolescent
Immunology
Population
Biophysics
Acquired immunodeficiency syndrome (AIDS)
medicine
Humans
education
HHV-8
business.industry
Infant
Cell Biology
medicine.disease
Infectious Disease Transmission
Vertical
lcsh:Biology (General)
Immunoglobulin G
Lytic-IFA
HIV-1
Epidemiologic Methods
business
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 38, Iss 2, Pp 237-240 (2005)
Brazilian Journal of Medical and Biological Research, Volume: 38, Issue: 2, Pages: 237-240, Published: FEB 2005
Popis: Human herpesvirus-8 (HHV-8) appears to be transmitted mainly by sexual contact. However, several studies suggest that in developing countries the infection may be acquired early in life by routes other than sexual transmission. The present study estimated the seroprevalence of HHV-8 in Brazilian children born to HIV-1-infected mothers. The serum samples were collected in a cross-sectional cohort study from 99 children born to HIV-infected mothers (median age 3.27 years; range 1.5-13.8 years) attending the outpatient clinic of the Federal University of Sao Paulo. IgG antibodies to HHV-8 latency-associated nuclear antigen and lytic phase antigens were detected by immunofluorescence assays. The samples tested were collected from children aged 12 months or older to exclude the possibility of cross-placental antibody transport. The total prevalence of anti-lytic antibodies in this population (5/99; 5%) reveals that HHV-8 infection can occur during childhood. Children aged 1.5 to 2 years had a seroprevalence of 2% (1/50) and children aged 3.25 to 13.8 years had a seroprevalence of 8% (4/49). This difference was not statistically significant, probably because of the small size of the sample, but it suggests that HHV-8 infection occurs more commonly late in infancy. Further prospective studies are necessary to evaluate the timing and risk factors for primary HHV-8 infection in the pediatric population.
Databáze: OpenAIRE
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