Evaluation of metabolic profile and C‐reactive protein concentrations in brachycephalic dogs with upper airway obstructive syndrome
| Autor: | Silvia Roncone, Federica Fietta, Paola Gianella, E. Bottero, Paolo Buracco, Claudio Bellino, Roberta Caccamo, Fabio Ostanello, Marco Pietra |
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| Přispěvatelé: | Gianella, Paola, Caccamo, Roberta, Bellino, Claudio, Bottero, Enrico, Fietta, Federica, Roncone, Silvia, Ostanello, Fabio, Pietra, Marco, Buracco, Paolo |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Nutrition/Metabolism Gastrointestinal Diseases Standard Article Gastroenterology Craniosynostoses Insulin resistance Dogs Internal medicine medicine Animals Dog Diseases Prospective Studies glucose plasma lipoprotein electrophoresis triglycerides Inflammation lcsh:Veterinary medicine fructosamine General Veterinary biology cholesterol fructosamine glucose plasma lipoprotein electrophoresis triglycerides business.industry Stomach C-reactive protein cholesterol Airway obstruction medicine.disease Hypoplasia Standard Articles Obstructive sleep apnea Airway Obstruction medicine.anatomical_structure C-Reactive Protein biology.protein Metabolome lcsh:SF600-1100 Female SMALL ANIMAL business Esophagitis Dyslipidemia |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of Veterinary Internal Medicine, Vol 33, Iss 5, Pp 2183-2192 (2019) |
| Popis: | Background Brachycephalic dogs have abnormal breathing patterns similar to those in humans with obstructive sleep apnea syndrome. Obstructive sleep apnea syndrome is associated with dyslipidemia, hyperglycemia, and insulin resistance. Despite the fact that anatomic and functional alterations are well described in brachycephalic dogs, little is known about the consequences of upper airway obstruction on systemic inflammatory response and metabolic profile. Objectives To describe history, clinical presentation, and anatomic abnormalities; to evaluate systemic inflammatory response and metabolic profile; and to identify possible associations among clinical signs, anatomic abnormalities, inflammatory response, and metabolic profile in brachycephalic dogs with airway obstruction. Animals Thirty purebred brachycephalic dogs with brachycephalic airway obstructive syndrome (BAOS). Methods Prospective study. The following information was recorded and studied: respiratory and digestive signs, airway and digestive endoscopic anomalies, presence or absence of tracheal hypoplasia, histologic evaluation of gastrointestinal tract biopsy specimens, serum concentrations of C-reactive protein (CRP), fructosamine, insulin, glucose, triglyceride, cholesterol, and plasma concentrations of lipoprotein classes. Results A high proportion of dogs (76.7%) had gastrointestinal signs. Esophageal deviation, atony of the cardia of the stomach, and distal esophagitis were the most common endoscopic anomalies detected. Twenty-six (86.6%) dogs had different degrees of laryngeal collapse. Gastrointestinal histologic evaluation identified mostly chronic inflammation. Glucose, fructosamine, triglycerides, cholesterol, CRP, pre-beta, beta lipoproteins, and chylomicrons were increased to a variable extent. Significant associations among clinical signs, anatomic abnormalities, CRP, and metabolic profile were not found. Conclusion and clinical importance Despite the presence of inflammation and some mild metabolic derangements, the clinicopathological variables evaluated did not offer valuable information in dogs with BAOS. |
| Databáze: | OpenAIRE |
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