Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial
| Autor: | Beom Joon Kim, Jang Mi Suk, Kyo Tan Koo, Jin Oh Park, Yoo Mi Choi, In Young Oh, Do Hyun Lee, Sang Wook Jung |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Niacinamide medicine.medical_specialty Administration Topical Skin Cream Dermatology law.invention Double blind Randomized controlled trial Double-Blind Method law Hyperpigmentation Medicine Humans Facial hyperpigmentation Emollients business.industry Middle Aged Antifibrinolytic Agents Regimen Drug Combinations Treatment Outcome Tranexamic Acid Delayed-Action Preparations Vitamin B Complex Female Dermatologic Agents business After treatment Tranexamic acid Facial Dermatoses Lighter skin color medicine.drug |
| Zdroj: | Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 20(2) |
| ISSN: | 1600-0846 |
| Popis: | Background Facial hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin color. Thus, there is a need for the development of skin lightening agents, and niacinamide and tranexamic acid (TXA) are promising candidates. Objective To assess the effectiveness of a combination of niacinamide and TXA as a topical moisturizing formulation for treatment of irregular facial pigmentation. Materials and Methods A total of 42 Korean women (age range: 30–60 years) who were not pregnant, nursing, or undergoing any concurrent therapy were enrolled in this study for 8 weeks. Subjects used a twice-daily regimen of either a moisturizing cream containing 2% niacinamide + 2% TXA (test formulation; n = 21) or cream vehicles (vehicle control; n = 21) in addition to an assigned sunscreen each morning. Pigmentation was measured objectively using a mexameter and chromameter, in addition to physicians' assessment using clinical photographs. Results The niacinamide + TXA formulation regimen was significantly (P |
| Databáze: | OpenAIRE |
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