| Autor: |
Akosua B. Anane-Adjei, Esther Jacobs, Samuel C. Nash, Sean Askin, Ramesh Soundararajan, Mary Kyobula, Jonathan Booth, Andrew Campbell |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
International journal of pharmaceutics. 614 |
| ISSN: |
1873-3476 |
| Popis: |
The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates much of the early drug development portfolio and poses a major challenge in pharmaceutical development. Polymer-based amorphous solid dispersions (ASDs) are becoming increasingly common and offer a promising formulation strategy to tackle the solubility and oral absorption issues of these APIs. This review discusses the design, manufacture, and utilisation of ASD formulations in preclinical drug development, with a key focus on the pre-formulation assessments and workflows employed at AstraZeneca. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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