Recovering genotypes and phenotypes using allele-specific genes
Autor: | Mark Gerstein, Gamze Gürsoy, Sarah Wagner, Nancy Lu |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Genome Biology, Vol 22, Iss 1, Pp 1-9 (2021) Genome Biology |
Popis: | With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum. Supplementary Information The online version contains supplementary material available at 10.1186/s13059-021-02477-x. |
Databáze: | OpenAIRE |
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