Recovering genotypes and phenotypes using allele-specific genes

Autor:	Mark Gerstein, Gamze Gürsoy, Sarah Wagner, Nancy Lu
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Genetics Genotype QH301-705.5 Short Report RNA Biology QH426-470 Polymorphism Single Nucleotide Human genetics Phenotype Genotype-phenotype distinction Gene expression Humans Biology (General) Gene Alleles Allele specific
Zdroj:	Genome Biology, Vol 22, Iss 1, Pp 1-9 (2021) Genome Biology
Popis:	With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum. Supplementary Information The online version contains supplementary material available at 10.1186/s13059-021-02477-x.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db724b12b5d686eeedc18bd42b82796e https://doaj.org/article/81a41c5bba57448eb9f65fcf149e6984 Zobrazit plný text záznamu