Down syndrome B-lymphocyte subpopulations, intrinsic defect or decreased T-lymphocyte help
| Autor: | Maaike A A Kusters, Ruud H J Verstegen, Esther de Vries, Eugenie F.A. Gemen |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Down syndrome Health aging / healthy living [IGMD 5] Adolescent B-Lymphocyte Subsets Immunoglobulins Immunophenotyping Young Adult Immune system Immunity T-Lymphocyte Subsets medicine Humans Child Respiratory Tract Infections Retrospective Studies biology Common variable immunodeficiency CD23 Immunologic Deficiency Syndromes Infant T lymphocyte T-Lymphocytes Helper-Inducer medicine.disease Immunity Humoral Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Female Antibody Down Syndrome |
| Zdroj: | Pediatric Research, 67, 563-9 Pediatric Research, 67, 5, pp. 563-9 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Down syndrome (DS) is known for increased incidence of respiratory infections and autoimmune diseases, indicating impaired immunity. Until now, attention has been mainly focused on T lymphocytes. Therefore, we determined B-lymphocyte subpopulations in 95 children with DS compared with 33 age-matched control (AMC) children. DS serum immunoglobulin levels were compared with 962 non-DS children with recurrent infections. The results were combined with clinical data. Transitional and naive B lymphocytes are profoundly decreased in the children with DS. This could be caused by an intrinsic B-lymphocyte defect resulting in (partial) failure of B-lymphocyte generation, decreased antigen-induced proliferation and/or increased apoptosis, or by decreased proliferation due to deficient T-lymphocyte help, or a combination of these. The decreased CD27, CD21, and CD23 cells are reminiscent of common variable immunodeficiency and suggestive of disturbed peripheral B-lymphocyte maturation. Immunoglobulin levels in DS are abnormal-as has been described before-and different from non-DS children with recurrent infections. We conclude that the humoral immune system is abnormal in DS, but could not find a relation between B-lymphocyte subsets, immunoglobulins and clinical features of the children with DS in our cohort, nor could we answer the question whether DS lymphocytes are truly intrinsically deficient, or could all findings be explained by deficient T-lymphocyte help. |
| Databáze: | OpenAIRE |
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