Hospitalizations and mortality among patients with fetal alcohol spectrum disorders: a prospective study
Autor: | Sarah Soyeon Oh, Sohee Park, Chung Mo Nam, Eun Cheol Park, Young Ju Kim, Sung In Jang |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Pediatrics Physiology lcsh:Medicine Comorbidity 0302 clinical medicine Pregnancy Risk Factors Neoplasms Medicine Prospective Studies 030212 general & internal medicine Prospective cohort study lcsh:Science reproductive and urinary physiology education.field_of_study Multidisciplinary Hazard ratio Middle Aged female genital diseases and pregnancy complications Hospitalization Neurology Fetal Alcohol Spectrum Disorders Prenatal Exposure Delayed Effects Cohort Population study Female Adult medicine.medical_specialty Population Article Young Adult 03 medical and health sciences Medical research Humans education Aged Proportional Hazards Models Proportional hazards model business.industry lcsh:R medicine.disease Socioeconomic Factors Attributable risk lcsh:Q Nervous System Diseases business 030217 neurology & neurosurgery Neuroscience |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) Scientific Reports |
ISSN: | 2045-2322 2019-0174 |
Popis: | With nearly 10% of women consuming alcohol during pregnancy, fetal alcohol spectrum disorders (FASDs) are becoming an increasing concern for clinicians and policymakers interested in the field of healthcare. Known as the range of mental and/or physical disabilities that occur among individuals with prenatal alcohol exposure, FASDs can result in dysmorphic features, problems with physical growth, neurobehavioral and cognitive problems that not only increase risk of various diseases, but also premature mortality. We investigated whether the diagnosis of FASDs result in increased risk of hospitalizations and mortality, with respect to FASD domains and relative diseases, when age effects are controlled for. The data for this study was taken from the National Health Insurance Service – National Sample Cohort (NHIS-NSC) between 2003 and 2013. The population attributable risk (PAR) statistic was used to estimate the percentage of hospitalizations and mortality attributable to FASDs and other factors. A time-dependent Cox proportional hazards model with age of diagnosis as the time-scale was employed to calculate adjusted hazard ratios and 95% CIs for hospitalizations and mortality among FASD populations compared to their general population peers. Among the 3,103 FASD cases, 27.5% experienced hospitalizations and 12.5% died. Overall, FASDs accounted for 853 FASD-attributable hospitalizations (51.0% of all hospitalizations in the study population) and 387 mortality events (34.5% of all deaths in the study population). 20.52% of hospitalizations and 21.35% of mortalities were attributable to FASDs in this population. Compared to the control group, FASD patients had a 1.25-fold (HR: 1.25, 95% CI: 1.05–1.49, p = 0.0114) increased risk of hospitalizations and a 1.33-fold (HR: 1.33, 95% CI: 1.07–1.67, p = 0.0118) increased risk of all-cause mortality. The most common cause for hospitalization was diseases of the nervous system, which accounted for 450 FASD-attributable hospitalizations (96.2% of all nervous system hospitalizations in the study population). In fact, FASD patients were 52 times more likely to be hospitalized for nervous system diseases than their peers (HR: 51.78, 95% CI: 29.09–92.17, p Trial Registration: Institutional Review Board of Yonsei University’s Health System: Y-2019-0174. |
Databáze: | OpenAIRE |
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