Hospitalizations and mortality among patients with fetal alcohol spectrum disorders: a prospective study

Autor: Sarah Soyeon Oh, Sohee Park, Chung Mo Nam, Eun Cheol Park, Young Ju Kim, Sung In Jang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Pediatrics
Physiology
lcsh:Medicine
Comorbidity
0302 clinical medicine
Pregnancy
Risk Factors
Neoplasms
Medicine
Prospective Studies
030212 general & internal medicine
Prospective cohort study
lcsh:Science
reproductive and urinary physiology
education.field_of_study
Multidisciplinary
Hazard ratio
Middle Aged
female genital diseases and pregnancy complications
Hospitalization
Neurology
Fetal Alcohol Spectrum Disorders
Prenatal Exposure Delayed Effects
Cohort
Population study
Female
Adult
medicine.medical_specialty
Population
Article
Young Adult
03 medical and health sciences
Medical research
Humans
education
Aged
Proportional Hazards Models
Proportional hazards model
business.industry
lcsh:R
medicine.disease
Socioeconomic Factors
Attributable risk
lcsh:Q
Nervous System Diseases
business
030217 neurology & neurosurgery
Neuroscience
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
ISSN: 2045-2322
2019-0174
Popis: With nearly 10% of women consuming alcohol during pregnancy, fetal alcohol spectrum disorders (FASDs) are becoming an increasing concern for clinicians and policymakers interested in the field of healthcare. Known as the range of mental and/or physical disabilities that occur among individuals with prenatal alcohol exposure, FASDs can result in dysmorphic features, problems with physical growth, neurobehavioral and cognitive problems that not only increase risk of various diseases, but also premature mortality. We investigated whether the diagnosis of FASDs result in increased risk of hospitalizations and mortality, with respect to FASD domains and relative diseases, when age effects are controlled for. The data for this study was taken from the National Health Insurance Service – National Sample Cohort (NHIS-NSC) between 2003 and 2013. The population attributable risk (PAR) statistic was used to estimate the percentage of hospitalizations and mortality attributable to FASDs and other factors. A time-dependent Cox proportional hazards model with age of diagnosis as the time-scale was employed to calculate adjusted hazard ratios and 95% CIs for hospitalizations and mortality among FASD populations compared to their general population peers. Among the 3,103 FASD cases, 27.5% experienced hospitalizations and 12.5% died. Overall, FASDs accounted for 853 FASD-attributable hospitalizations (51.0% of all hospitalizations in the study population) and 387 mortality events (34.5% of all deaths in the study population). 20.52% of hospitalizations and 21.35% of mortalities were attributable to FASDs in this population. Compared to the control group, FASD patients had a 1.25-fold (HR: 1.25, 95% CI: 1.05–1.49, p = 0.0114) increased risk of hospitalizations and a 1.33-fold (HR: 1.33, 95% CI: 1.07–1.67, p = 0.0118) increased risk of all-cause mortality. The most common cause for hospitalization was diseases of the nervous system, which accounted for 450 FASD-attributable hospitalizations (96.2% of all nervous system hospitalizations in the study population). In fact, FASD patients were 52 times more likely to be hospitalized for nervous system diseases than their peers (HR: 51.78, 95% CI: 29.09–92.17, p Trial Registration: Institutional Review Board of Yonsei University’s Health System: Y-2019-0174.
Databáze: OpenAIRE
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