Decreased Levels of S-100 Protein in Non-ulcer Interstitial Cystitis
| Autor: | Sonny L. Johansson, Ralph Peeker, Magnus Fall, Kenneth G. Haglid, Frank Aldenborg, Lars Rosengren |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Biopsy Urology Urinary Bladder Cystitis Interstitial Disease Pathogenesis medicine Humans Aged medicine.diagnostic_test business.industry S100 Proteins Case-control study Interstitial cystitis medicine.disease Peripheral medicine.anatomical_structure Nephrology Case-Control Studies Etiology Female Neuron business |
| Zdroj: | Scandinavian Journal of Urology and Nephrology. 32:395-398 |
| ISSN: | 1651-2065 0036-5599 |
| DOI: | 10.1080/003655998750015179 |
| Popis: | Interstitial cystitis (IC) is a chronic debilitating condition which mainly affects women. Accumulated evidence indicates that IC is a heterogeneous syndrome. As compared to classic IC, the non-ulcer type of IC appears to be different concerning symptomatic, endoscopical and histological findings, as well as in response to various forms of treatment. S-100 is a neural protein considered to be located primarily in the axons. To explore further the neurogenic nature of the disease, we compared bladder wall S-100 content in controls and in patients with classic and non-ulcer IC. We noticed a decrease in S-100 content in non-ulcer IC as compared to controls. This may be an expression of altered peripheral innervation in non-ulcer IC, which, in turn, may be an indication of primary neurogenic etiology. The difference in S-100 content between classic and non-ulcer IC supports the hypothesis that they represent separate entities, which may explain differences in response to various treatments. |
| Databáze: | OpenAIRE |
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