Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis
| Autor: | Hisashi Masuyama, Hideki Nakatsukasa, Yuji Hiramatrsu, Akio Masumoto, Naoko Suwaki, Yoko Tateishi |
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| Rok vydání: | 2005 |
| Předmět: |
Placental growth factor
Adult Vascular Endothelial Growth Factor A medicine.medical_specialty Angiogenesis Neovascularization Physiologic Pregnancy Proteins Preeclampsia chemistry.chemical_compound Glomerulonephritis Pre-Eclampsia Pregnancy Internal medicine medicine Humans reproductive and urinary physiology Placenta Growth Factor Fetus Proteinuria Vascular Endothelial Growth Factor Receptor-1 business.industry Obstetrics and Gynecology medicine.disease Vascular Endothelial Growth Factor Receptor-2 female genital diseases and pregnancy complications Vascular endothelial growth factor Pregnancy Complications Endocrinology chemistry embryonic structures Chronic Disease Female medicine.symptom business Tyrosine kinase |
| Zdroj: | American journal of obstetrics and gynecology. 194(2) |
| ISSN: | 1097-6868 |
| Popis: | Objective Recently, reports have indicated that the imbalance of circulating angiogenic factors is important in the onset of preeclampsia. In this study we investigated angiogenic factor levels in women with preeclampsia, preeclampsia superimposed on chronic glomerulonephritis, gestational proteinuria, and normal pregnancies. Study design We measured several circulating angiogenic factors, placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase-1, and soluble fetal liver kinase-1. Results Compared with women with normal pregnancies, placental growth factor concentrations were lower, and soluble fms-like tyrosine kinase 1 concentrations were higher in women with preeclampsia and gestational proteinuria; soluble fms-like tyrosine kinase 1 concentrations were also higher in women with preeclampsia superimposed on chronic glomerulonephritis. Conclusion There were obvious differences in the levels of circulating angiogenic factors placental growth factor and soluble fms-like tyrosine kinase 1 among preeclampsia, gestational proteinuria, and controls. The imbalance of angiogenic factors is important in the onset of preeclampsia superimposed on chronic glomerulonephritis. |
| Databáze: | OpenAIRE |
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