The HLA-DQ(α1*0102, β1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(α1*01, β1*1501) heterodimer
| Autor: | Ingebjørg Knutsen, Frode Vartdal, Elisabeth Gulowsen Celius, Erik Thorsby, Anne Spurkland, Beiske A |
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| Rok vydání: | 1997 |
| Předmět: |
Multiple Sclerosis
Genotype Protein Conformation Immunology Alpha (ethology) Biochemistry HLA-DQ alpha-Chains Beta-1 adrenergic receptor HLA-DQ Antigens HLA-DQ Genetics HLA-DR HLA-DQ beta-Chains Humans Immunology and Allergy Allele Alleles HLA-DR Antigen HLA-DQ Antigen Chemistry Haplotype HLA-DR Antigens General Medicine Molecular biology Haplotypes Disease Susceptibility Dimerization HLA-DRB1 Chains |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1997.tb02828.x |
| Popis: | The frequencies of DR2, DQ6-related DRB1, DQA1, DQB1 haplotypes were compared in 181 multiple sclerosis patients and 294 controls in Norway. All individuals carried either DR2 or DQ6, i.e., the DQ(alpha 1*0102, beta 1*0602) heterodimer. The DR(alpha 1*01, beta 1*1501) and the DQ(alpha 1*0102, beta 1*0602) heterodimers were carried by 171 of the patients (94%) and 289 (98%) of the controls. Seven of the patients and one of the controls carried the DQ(alpha 1*0102, beta 1*0603) heterodimer together with the DR(alpha 1*01, beta 1*1501) heterodimer. Two patients carried the DQ(alpha 1*0102, beta 1*0602) heterodimer in the absence of the DR( alpha 1*01, beta 1*1501) heterodimer. The DR(alpha 1*01, beta 1*1501) heterodimer was not observed in the absence of the DQ(alpha 1*0102, beta 1*0602) heterodimer or the DQ(alpha 1*0102, beta 1*0603) heterodimer, neither in the patients nor in the controls. Our findings indicate that the genes encoding the DQ(alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to developing multiple sclerosis in the absence of the DRB1*1501 allele. |
| Databáze: | OpenAIRE |
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