Associations between COMTVal158Met polymorphism and cognition: direct or indirect effects?
| Autor: | Jim van Os, Pilar Isusi, Sergi Papiol, Elena Echevarria, Ainhoa Martín-Pagola, Jose Ramon Bilbao, Luis Castaño, Paloma Galdos, Lydia Krabbendam |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Risk Psychosis Genotype Neuropsychological Tests Catechol O-Methyltransferase Genetic determinism Schizotypal Personality Disorder 03 medical and health sciences Methionine 0302 clinical medicine Polymorphism (computer science) Reaction Time medicine Humans Attention Genetic Predisposition to Disease Genotyping Alleles Genetics Polymorphism Genetic Catechol-O-methyl transferase Valine Cognition Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Schizophrenia Female Cognition Disorders Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | European Psychiatry. 21:338-342 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2006.03.007 |
| Popis: | Background:Previous work suggests that reaction time variability (RTV) in attentional tasks, as a measure of cognitive stability, is associated with degree ofValloading in COMTVal158Metgenotype, and that this association may be relevant for the aetiology of schizophrenia. This study examined (i) to what degree RTV pertaining to tasks of varying cognitive complexity would be associated with increased risk for schizophrenia and (ii) to what degree this would be mediated byValloading.Methods:COMT genotyping was investigated in a sample of 23 patients with schizophrenia, 33 first-degree relatives, and 21 controls. All participants performed the Flanker continuous performance test.Results:Schizophrenia liability was associated with number of correct trials of the Flanker test, but not with RTV, and this association was not mediated by COMTVal158Metgenotype. Similarly,Metloading was associated with number of correct trials and with RTV, but this was not mediated by schizophrenia liability.Conclusions:Associations between COMTVal158Metgenotype and RTV do not appear to reflect transmission of schizophrenia liability in families. Differential associations withValandMetalleles across studies suggest indirect effects through gene–gene interactions or the influence of a functional polymorphism near COMTVal158Met. |
| Databáze: | OpenAIRE |
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