The role of the immune response mediator genes polymorphism in the predisposition to juvenile idiopathic arthritis
| Autor: | A. B. Bakirov, T. V. Viktorova, K.V. Danilko, V.A. Malievsky, L.S. Nazarova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
Medicine (General) Arthritis chemical and pharmacologic phenomena Biology 03 medical and health sciences 0302 clinical medicine Mediator Immune system R5-920 immune system diseases medicine Juvenile skin and connective tissue diseases Gene 030304 developmental biology 030203 arthritis & rheumatology 0303 health sciences association General Medicine medicine.disease predisposition polymorphic loci sexual dimorphism Immunology juvenile idiopathic arthritis |
| Zdroj: | Russian Open Medical Journal, Vol 8, Iss 4, p e0408 (2019) |
| ISSN: | 2304-3415 |
| Popis: | Objective ― The aim of the work was to study the contribution of the immune response mediator genes polymorphism (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, PADI4 rs2240336) to the formation of the predisposition to juvenile idiopathic arthritis (JIA) and its clinical variants. Material and Methods ― The JIA group included 330 patients and the control group – 342 volunteers without autoimmune diseases from the Republic of Bashkortostan, Russia. Genotyping was conducted by the real-time polymerase chain reaction. Results ― Taking into account the differences by sex, it was established, that the alleles/genotypes of the TNFA rs1800629, LTA rs909253, IL2-IL21 rs6822844, PTPN22 rs2476601 polymorphic loci and the TNFA rs1800629*G – LTA rs909253*G haplotype are associated with the development of JIA as a whole (p |
| Databáze: | OpenAIRE |
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