STIMULATION OF GONADOTROPHIN SECRETION WITH THE PREGNANCY INHIBITOR d-6-METHYL-8-CYANOMETHYLERGOLINE (I)
| Autor: | K. Rezabek, O. Marhan, M. Semonsky, M. Seda |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
endocrine system
Embryology medicine.medical_specialty medicine.medical_treatment Stimulation Biology Muscle hypertrophy chemistry.chemical_compound Endocrinology Contraceptive Agents Thiocarbamates Internal medicine medicine Animals Endocrine system Castration Methallibure Ergolines Saline Ovary Obstetrics and Gynecology Organ Size Cell Biology Luteinizing Hormone Rats Hydrazines Reproductive Medicine chemistry Hypothalamus Pituitary Gland Gonadotropins Pituitary Female Follicle Stimulating Hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Reproduction. 24:263-265 |
| ISSN: | 1741-7899 1470-1626 |
| DOI: | 10.1530/jrf.0.0240263 |
| Popis: | Ovarian weight in rats administered physiological saline .5 mg D-6-methyl-8-cyanomethylergoline (6605 VUFB) or 1 mg 6605 VUFB by gavage daily Days 1 to 12 (Day 1 = unilateral ovariectomy) increased 47% 83% and 115% respectively over ovarian weight in intact rats given saline (p = .01 in each case). 6605 VUFB may induce secretion of hypophysial gonadotrophin by stimulating the hypothalamus to release FSH - and LH-releasing and prolactin-inhibiting factors. Daily treatment of unilaterally ovariactomized rats with 12 mg methallibure an inhibitor of gonadotrophin secretion followed by 1 mg 6605 VUFH resulted in no hypertrophy. |
| Databáze: | OpenAIRE |
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