Salivary interleukin-1β: Oral inflammatory biomarker in patients with psoriasis
| Autor: | Andrea Santarelli, Ivan Bobyr, Giulia Ganzetti, Elisa Molinelli, Giulia Di Ruscio, Annamaria Offidani, Anna Campanati, Davide Sartini, Monica Emanuelli, Valerio Brisigotti |
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| Rok vydání: | 2016 |
| Předmět: |
Necrosis
oral biomarker Biochemistry TNF-α inhibitor treatment 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis medicine In patient business.industry Gene/Molecular Research on Immune-Mediated Diseases Biochemistry (medical) Interleukin psoriasis Cell Biology General Medicine medicine.disease Interleukin 1β IL-1β 030220 oncology & carcinogenesis Immunology Tumor necrosis factor alpha medicine.symptom Inflammatory biomarker business After treatment |
| Zdroj: | The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060515598902 |
| Popis: | Objective To evaluate salivary interleukin (IL)-1β levels in patients with psoriasis, before and after treatment with tumour necrosis factor (TNF)-α inhibitors. Methods In this pilot study, salivary secretions were collected from patients with psoriasis and untreated healthy control subjects at baseline, and from patients after 12 weeks’ treatment with TNF-α inhibitors. IL-1β levels were determined in saliva samples via enzyme-linked immunosorbent assays, undertaken before and after TNF-α inhibitor treatment. Psoriasis-specific analysis of disease severity and activity were also undertaken. Results At baseline, patients ( n = 25) had significantly higher salivary IL1β levels than controls ( n = 20). In patients with psoriasis, TNF-α inhibitor treatment resulted in significantly reduced IL1β levels compared with baseline, but IL1β levels remained significantly higher than in control subjects even after treatment. There was a positive correlation between IL-1β levels, psoriasis activity and disease index score after TNF-α inhibitor treatment. Conclusion Saliva is a valid noninvasive tool for monitoring inflammation in psoriasis. TNF-α inhibitor treatments appear to interfere with the oral inflammatory process in patients with psoriasis. |
| Databáze: | OpenAIRE |
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