Efficacy of daiokanzoto in chronic constipation refractory to first-line laxatives
| Autor: | Kouji Tanaka, Tomoaki Yoshimura, Machiko Kurimoto, Kouki Mori, Aya Yoshida, Atsuko Takeda, Tadashi Sugiyama, Tatsuya Hirose, Yuki Kawachi, Yasutaka Shinoda |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Constipation Senna Kampo medicine.medical_treatment Laxative Gastroenterology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Refractory Internal medicine medicine General Pharmacology Toxicology and Pharmaceutics Adverse effect Chronic constipation biology business.industry General Neuroscience digestive oral and skin physiology Articles General Medicine biology.organism_classification Surgery Defecation 030211 gastroenterology & hepatology medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Biomedical Reports. 5:497-500 |
| ISSN: | 2049-9442 2049-9434 |
| DOI: | 10.3892/br.2016.754 |
| Popis: | There are only a few treatment options for constipation and limited evidence of suitable treatments. Daiokanzoto (DKT) is a Kampo medicine often used clincally to treat constipation. DKT is a laxative used predominantly in Japan; however, clinical data on its efficacy and safety is lacking. Patients who used DKT, but were intolerant to either magnesium oxide (MgO; MgO group; n=16) or senna extract (Senna group; n=26) were included in the present study. The frequencies of their bowel movements were compared during the 1 week prior to and following DKT administration. Within 24 hours after DKT administration, 93.8% of the patients in the MgO group evacuated their bowels. The median bowel movement frequency 1 week prior to DKT administration was 2.5 and 1 week after DKT administration was significantly increased to 7.5. In the Senna group, within 24 h of DKT administration, 80.8% of the patients evacuated their bowels. The median bowel movement frequency 1 week prior to the DKT treatment was 2.0, which significantly increased to 8.5 1 week after the administration of DKT. The adverse events from DKT treatment were mild and controllable. |
| Databáze: | OpenAIRE |
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