The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles : an analysis from the Ovarian Cancer Cohort Consortium (OC3)
| Autor: | Kim Overvad, Patricia Hartge, Roger L. Milne, Kim Robien, Graham G. Giles, Louise A. Brinton, Katie M. O'Brien, Alpa V. Patel, Edwin S. Iversen, Rudolf Kaaks, Lynne R. Wilkens, Renée T. Fortner, Anne Zeleniuch-Jacquotte, Ruth C. Travis, Alicja Wolk, Catherine Schairer, Mia M. Gaudet, I-Min Lee, Britton Trabert, Inger T. Gram, Anthony J. Swerdlow, Veronica Wendy Setiawan, Emily White, Leo J. Schouten, Nicolas Wentzensen, Dale P. Sandler, Shelley S. Tworoger, Victoria A. Kirsh, Thomas E. Rohan, Mary K. Townsend, Julie E. Buring, Piet A. van den Brandt, Leslie Bernstein, Antonia Trichopoulou, Elio Riboli, K Visvanathan, N. Charlotte Onland-Moret, Marina Kvaskoff, James V. Lacey, Ulrike Peters, Judith A. Hoffman Bolton, Alan A. Arslan, Laure Dossus, Jenny N. Poynter, Holly R. Harris, Michael Jones, Gary E. Fraser, Annika Idahl, Pilar Amiano, Synnove F. Knutsen |
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| Přispěvatelé: | Epidemiologie, RS: GROW - R1 - Prevention |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research endocrine system diseases 0302 clinical medicine Risk Factors Prospective Studies Prospective cohort study Reproductive History MUTANT P53 media_common Ovarian Cancer Cohort Consortium (OC3) Ovarian Neoplasms HYPOTHESIS ORAL-CONTRACEPTIVES CARCINOGENESIS Absolute risk reduction Middle Aged female genital diseases and pregnancy complications Serous fluid medicine.anatomical_structure 030220 oncology & carcinogenesis INCESSANT OVULATION Female Life Sciences & Biomedicine Ovulation medicine.medical_specialty CARCINOMA media_common.quotation_subject Ovary Risk Assessment Article 03 medical and health sciences ANDROGENS Contraceptive Agents INFLAMMATION Internal medicine medicine Journal Article Humans 1112 Oncology and Carcinogenesis Oncology & Carcinogenesis REPRODUCTIVE FACTORS Fallopian Tubes Aged Proportional Hazards Models Science & Technology Cancer prevention business.industry medicine.disease 030104 developmental biology OVEREXPRESSION business Ovarian cancer Fallopian tube |
| Zdroj: | Trabert, B, Tworoger, S S, O'Brien, K M, Townsend, M K, Fortner, R T, Iversen, E S, Hartge, P, White, E, Amiano, P, Arslan, A A, Bernstein, L, Brinton, L A, Buring, J E, Dossus, L, Fraser, G E, Gaudet, M M, Giles, G G, Gram, I T, Harris, H R, Hoffman Bolton, J, Idahl, A, Jones, M E, Kaaks, R, Kirsh, V A, Knutsen, S F, Kvaskoff, M, Lacey, J V, Lee, I-M, Milne, R L, Onland-Moret, N C, Overvad, K, Patel, A V, Peters, U, Poynter, J N, Riboli, E, Robien, K, Rohan, T E, Sandler, D P, Schairer, C, Schouten, L J, Setiawan, V W, Swerdlow, A J, Travis, R C, Trichopoulou, A, van den Brandt, P A, Visvanathan, K, Wilkens, L R, Wolk, A, Zeleniuch-Jacquotte, A, Wentzensen, N & Ovarian Cancer Cohort Consortium (OC3) 2020, ' The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles : an analysis from the Ovarian Cancer Cohort Consortium (OC3) ', Cancer Research, vol. 80, no. 5, pp. 1210-1218 . https://doi.org/10.1158/0008-5472.CAN-19-2850 Cancer Res Cancer Research, 80(5), 1210. American Association for Cancer Research Inc. Cancer Research, 80(5), 1210-1218. American Association for Cancer Research Inc. |
| ISSN: | 0008-5472 |
| Popis: | Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile ( Significance: Although ovarian cancer is rare, risk of most ovarian cancers doubles as the number of lifetime ovulatory cycles increases from approximately 300 to 500. Thus, identifying an important area for cancer prevention research. |
| Databáze: | OpenAIRE |
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