The association of aphasia and right-sided motor impairment in corticobasal syndrome
| Autor: | Stefan Lorenzl, Erik Mille, Thomas H. Bak, Armin Giese, Nibal Ackl, Johannes Levin, Benedikt Bader, Axel Rominger, Maximilian Patzig, Adrian Danek, Thomas Arzberger, Kai Bötzel |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty physiopathology [Basal Ganglia Diseases] Neurology Audiology Lateralization of brain function Functional Laterality physiopathology [Cerebral Cortex] etiology [Aphasia] Dysarthria Extrapyramidal symptoms Basal Ganglia Diseases Aphasia medicine Dementia Corticobasal degeneration Humans ddc:610 Aged Cerebral Cortex Aged 80 and over physiopathology [Dysarthria] Movement Disorders Parkinsonism etiology [Movement Disorders] physiology [Functional Laterality] physiopathology [Movement Disorders] Middle Aged medicine.disease physiopathology [Aphasia] Female Neurology (clinical) complications [Basal Ganglia Diseases] medicine.symptom Psychology Neuroscience |
| Zdroj: | Journal of neurology 262(10), 2241-2246 (2015). doi:10.1007/s00415-015-7833-1 Levin, J, Bak, T H, Rominger, A, Mille, E, Arzberger, T, Giese, A, Ackl, N, Lorenzl, S, Bader, B, Patzig, M, Bötzel, K & Danek, A 2015, ' The association of aphasia and right-sided motor impairment in corticobasal syndrome ', Journal of Neurology . https://doi.org/10.1007/s00415-015-7833-1 |
| ISSN: | 2003-2013 |
| DOI: | 10.1007/s00415-015-7833-1 |
| Popis: | Corticobasal syndrome is defined clinically on the basis of symptoms and findings related to dysfunction of the cerebral cortex and the basal ganglia. Usually, marked asymmetry of motor findings is observed. Although aphasia has now been recognized as a frequent feature of corticobasal syndrome, it remains unclear whether it is usually associated with right-sided motor symptoms, pointing to the involvement of the left hemisphere. Hence, we set out to examine the relationship between the presence of language symptoms and the side affected by extrapyramidal symptoms. We analyzed the electronic care records of patients seen in the years 2003-2013 in the Neurology Department of the University Hospital of Munich. The diagnosis of corticobasal syndrome was discussed in ninety-two individuals. Of those, 38 cases fulfilled diagnostic criteria for corticobasal syndrome. Aphasia correlated highly with a predominant right-sided movement disorder (p = 0.002). In contrast, it was less common in patients with left-sided motor presentation. Dysarthria did not show a preferential correlation (p = 0.25). Our analysis suggests a characteristic presentation of corticobasal syndrome in which motor dysfunction of the right side of the body is associated with aphasia. |
| Databáze: | OpenAIRE |
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