The Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes
Autor: | Caroline R. Juneau, Shelby A. Neal, Julia Kim, Emre Seli, Paul A. Bergh, Richard T. Scott, George Patounakis, Scott J. Morin |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty medicine.medical_treatment Fertilization in Vitro Overweight Body Mass Index 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Electric Impedance Humans Obesity Prospective Studies Adiposity 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Obstetrics Infant Newborn Obstetrics and Gynecology medicine.disease Abortion Spontaneous Low birth weight 030104 developmental biology Reproductive Medicine Private practice Body Composition Female Underweight medicine.symptom Live birth business Body mass index Live Birth |
Zdroj: | Fertility and sterility. 116(2) |
ISSN: | 1556-5653 |
Popis: | Objective To investigate the impact of obesity as determined by bioelectric impedance analysis (BIA) and body mass index (BMI) on in vitro fertilization (IVF) laboratory and clinical outcomes. Design Prospective cohort study. Setting Academic-affiliated private practice. Patient(s) A total of 1,889 infertile couples undergoing IVF from June 2016 to January 2019. Intervention(s) Female patients and male partners underwent BIA and BMI measurement at the time of oocyte retrieval. Embryology and clinical outcomes were prospectively tracked with comparison groups determined by percentage of body fat (%BF) and BMI categories. Main Outcome Measure(s) Fertilization rate, blastocyst formation rate, euploidy rate, miscarriage rate, sustained implantation rate, live birth rate, rates of low birth weight/very low birth weight, prematurity rates. Result(s) Fertilization rates and euploidy rates were equivalent among all women. Blastocyst formation rates were slightly higher (55%) in women with an obese %BF compared with all other %BF categories (51%); however, this trend was not noted in women defined as obese by BMI. Miscarriage rates, sustained implantation rates, and live birth rates were equivalent among all women. The rate of very low birth weight was low but increased in obese women (3%) versus underweight, normal-weight, and overweight counterparts (0%–1.3%) as determined by %BF and BMI. Obesity in men did not significantly affect any embryologic or clinical outcomes. Conclusion(s) Although maternal obesity imposes a small but increased risk of very low birth weight infants, most embryology and pregnancy outcomes are equivalent to normal weight patients. Paternal obesity does not appear to affect IVF, pregnancy, or delivery outcomes. |
Databáze: | OpenAIRE |
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