Alcohol consumption, homeostasis model assessment indices and blood pressure in middle-aged healthy men
| Autor: | Yuka Noborisaka, Yuichi Yamada, Ikiko Tsuritani, R Honda, S Yamada, Masao Ishizaki |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Cross-sectional study medicine.medical_treatment Population Blood Pressure Alcohol Models Biological Islets of Langerhans chemistry.chemical_compound Insulin resistance Reference Values Internal medicine Internal Medicine medicine Homeostasis Humans Gamma-glutamyltransferase education education.field_of_study biology business.industry Insulin nutritional and metabolic diseases gamma-Glutamyltransferase Middle Aged medicine.disease Cross-Sectional Studies Endocrinology Blood pressure chemistry biology.protein Regression Analysis Insulin Resistance business Body mass index |
| Zdroj: | Journal of Human Hypertension. 18:343-350 |
| ISSN: | 1476-5527 0950-9240 |
| Popis: | A total of 1595 middle-aged healthy men consuming alcohol up to 120 ml per day and 538 without alcohol consumption were recruited from an occupational population, and their insulin resistance (IR) and beta-cell function (BC) were measured using the homeostasis model assessment (HOMA-IR and HOMA-BC), and the associations with alcohol consumption, blood pressure (BP), and serum gamma-glutamyltransferase (GGT) levels were analysed cross-sectionally. Both HOMA-IR and HOMA-BC were decreased with increasing alcohol consumption, but HOMA-BC corresponding to a level of HOMA-IR was 4-10 and 8-20% lower in drinkers consuming less than 60 ml of alcohol per day and those consuming more, respectively, than in nondrinkers, suggesting an altered fasting serum insulin-glucose relationship in alcohol consumers. Although BP was higher and HOMA-IR was lower in alcohol consumers than in nonconsumers, BP was higher at higher HOMA-IR irrespective of alcohol consumption. Elevations of serum GGT were positively associated with BP and HOMA-IR in both alcohol consumers and nonconsumers. Multiple regression analyses in the subjects showed that elevated serum GGT was an independent contributor to HOMA-IR elevations, and both serum GGT and HOMA-IR were significantly related to BP elevations after adjusting for alcohol consumption, age, body mass index, cigarette consumption, and physical activity at leisure. Although cross-sectional observations do not provide evidence of causal association, the results suggest that elevated serum GGT in alcohol consumers relates to elevations of IR and that the elevated insulin resistance relates, at least partly, to BP elevations in alcohol consumers. |
| Databáze: | OpenAIRE |
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