Characterization of Mycotypha Metabolites Found to be Inhibitors of Cell Adhesion Molecules
| Autor: | Qinglin Zhang, Larry A. Walker, Satoshi Takamatsu, Kevin K. Schrader, Hala N. ElSohly |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cytochalasin E
Metabolite Intercellular Adhesion Molecule-1 HL-60 Cells CHO Cells Biology chemistry.chemical_compound Cricetinae Drug Discovery Cell Adhesion Tumor Cells Cultured Animals Humans Cytochalasin Cell adhesion Pharmacology Cell adhesion molecule Adhesion Flow Cytometry Cytochalasins Lymphocyte Function-Associated Antigen-1 In vitro chemistry Biochemistry Mucorales Cell Adhesion Molecules |
| Zdroj: | The Journal of Antibiotics. 55:585-592 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.55.585 |
| Popis: | Three inhibitors of cell adhesion based on LFA-1/ICAM-1 were isolated from the cultured broth of the fungal strain Mycotypha sp. UMF-006. These compounds were identified by spectroscopy to be cytochalasin E (1), 5,6-dehydro-7-hydroxy derivative of cytochalasin E (2) and delta 6,12-isomer of 2 (3). All these components inhibited adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 30 micrograms/ml for 1, 75 micrograms/ml for 2, and 90 micrograms/ml for 3. |
| Databáze: | OpenAIRE |
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