Transmission of Toxoplasma gondii in an urban population of domestic cats (Felis catus)

Autor: Eve Afonso, Philippe Thulliez, Emmanuelle Gilot-Fromont
Přispěvatelé: Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Biodémographie évolutive, Département écologie évolutive [LBBE], Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Protozooses Transmises par l'Alimentation (Cryptosporidiose, Giardose et Toxoplasmose) : Mode de Contamination et Pathogénie (PROTAL) - EA 3800 (PROTAL), Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), IPP Laboratoire de la Toxoplasmose, Institut de Puériculture et Périnatalogie, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
MESH: Urban Health
Epidemiology
Rain
Antibodies
Protozoan
Cat Diseases
Serology
law.invention
0403 veterinary science
Oocyst
0302 clinical medicine
law
Direct agglutination test
Prevalence
MESH: Animals
MESH: Immunoglobulin G
[SDV.EE]Life Sciences [q-bio]/Ecology
environment
education.field_of_study
MESH: Toxoplasmosis
Animal
biology
Feral cat
MESH: Toxoplasma
Antibody titer
Temperature
04 agricultural and veterinary sciences
MESH: Temperature
MESH: Infectious Disease Transmission
Vertical
Infectious Diseases
Transmission (mechanics)
Carrier State
France
MESH: Cats
MESH: Carrier State
Toxoplasma
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
040301 veterinary sciences
MESH: Population Density
030231 tropical medicine
Population
Toxoplasma gondii
03 medical and health sciences
Coccidia
parasitic diseases
Animals
MESH: Antibodies
Protozoan
education
MESH: Prevalence
Population Density
MESH: Cat Diseases
Urban Health
biology.organism_classification
Infectious Disease Transmission
Vertical
MESH: France
Toxoplasmosis
Animal
Immunoglobulin G
Immunology
Cats
Parasitology
MESH: Rain
Zdroj: International Journal for Parasitology
International Journal for Parasitology, Elsevier, 2006, 36, pp.1373-1382
International Journal for Parasitology, 2006, 36 (13), pp.1373-82. ⟨10.1016/j.ijpara.2006.07.010⟩
International Journal for Parasitology, Elsevier, 2006, 36 (13), pp.1373-82. ⟨10.1016/j.ijpara.2006.07.010⟩
International Journal for Parasitology, 2006, 36, pp.1373-1382
ISSN: 0020-7519
DOI: 10.1016/j.ijpara.2006.07.010⟩
Popis: International audience; Toxoplasma gondii is a protozoan parasite that infects humans and animal species worldwide. The relative importance of each potential transmission route in the complex life cycle of this coccidia is largely unknown, due to the lack of studies taking into account all routes simultaneously. In this study, we analyzed the transmission of T. gondii in an urban population of stray cats captured between 1993 and 2004. Analyzing prevalence, our aim was to determine which factors influence transmission in this population. Specific anti-T. gondii IgG antibodies were detected using the modified agglutination test. Firstly, we analyzed the kinetics of antibody titers in cats captured several times, using mixed linear models and correspondence analysis. We showed that antibody titers did not vary significantly with time and that titer 40 was the best threshold to separate individuals into two serological groups. Overall, prevalence was only 18.6%, thus transmission of T. gondii is infrequent in this population. As expected, a highly significant association was detected between age and presence of IgG antibodies. Prevalence was lowest in kittens aged 3-4 months, suggesting that newborn kittens may carry maternal antibodies and that vertical transmission is rare. After taking into account the effect of age, logistic regression showed that antibody carriage was related to factors that possibly related to the survival of oocysts: localization in the study site, origin of the cats, maximal temperatures and rain. Our results suggest that in this population, vertical transmission is rare, low predation limits prevalence, and oocyst survival is a determining factor in the risk of infection. We discuss the more general importance of conditions determining oocyst survival in the life cycle of T. gondii.
Databáze: OpenAIRE
Externí odkaz: