Blood metal levels and third trimester maternal plasma matrix metalloproteinases (MMPs)
| Autor: | Renaud Vincent, Mandy Fisher, William D. Fraser, Prem Kumarathasan, Erica Blais, Agnieszka Bielecki, Ajoy Basak, Felicia Au, Tye E. Arbuckle, Sabit Cakmak, James Gomes |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Environmental Engineering Pregnancy Trimester Third Health Toxicology and Mutagenesis chemistry.chemical_element Matrix metalloproteinase Arsenic Metal Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy Metals Heavy Odds Ratio medicine Humans Environmental Chemistry 030212 general & internal medicine Maternal-Fetal Exchange Manganese Cadmium 030219 obstetrics & reproductive medicine business.industry Infant Newborn Pregnancy Outcome Public Health Environmental and Occupational Health Mercury General Medicine General Chemistry Odds ratio medicine.disease Pollution Matrix Metalloproteinases 3. Good health Pregnancy Trimester First Lead chemistry Maternal Exposure In utero visual_art Cohort Immunology Toxicity visual_art.visual_art_medium Female business |
| Zdroj: | Chemosphere. 159:506-515 |
| ISSN: | 0045-6535 |
| Popis: | While it is known that in utero exposure to environmental toxicants, namely heavy metals, can adversely affect the neonate, there remains a significant paucity of information on maternal biological changes specific to metal exposures during pregnancy. This study aims at identifying associations between maternal metal exposures and matrix metalloproteinases (MMPs) that are known to be engaged in pregnancy process. Third trimester maternal plasma (n = 1533) from a pregnancy cohort (Maternal-Infant Research on Environmental Chemicals Study, MIREC) were analyzed for MMP-1,-2,-7,-9 and -10 by affinity-based multiplex protein array analyses. Maternal metal concentrations (mercury, cadmium, lead, arsenic and manganese) in 1st and 3rd trimesters exhibited strong correlations (p |
| Databáze: | OpenAIRE |
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