Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson's disease
| Autor: | Guillaume Brisson, Anne-Marie Castonguay, Martin Lévesque, Sarah Ben Youssef, Mohamed Amri, Charles Gora, Hélène Doucet-Beaupré |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Parkinson's disease Medicine (miscellaneous) Substantia nigra Apoptosis Pharmacology Biology medicine.disease_cause Neuroprotection 03 medical and health sciences Mice 0302 clinical medicine Dopamine medicine Neurotoxin Animals Vitis 030109 nutrition & dietetics Nutrition and Dietetics Grape Seed Extract Pars compacta General Neuroscience Dopaminergic Neurons Dopaminergic Parkinson Disease General Medicine medicine.disease 3. Good health Disease Models Animal Oxidative Stress Neuroprotective Agents nervous system 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Nutritional neuroscience. 24(3) |
| ISSN: | 1476-8305 |
| Popis: | Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta, and it involves oxidative stress. Our goal was to evaluate the neuroprotective effect of Vitis vinifera red grape seed and skin extract (GSSE) in a model of Parkinson's disease. GSSE is very rich in phenolic compounds, such as flavonoids, anthocyanins, catechins and stilbenes, which are present in the pulp, seeds, and leaves of the fruit. GSSE is known for its antioxidant properties and has shown beneficial effects against oxidative injury in different organs, such as the kidneys, liver, heart and brain. In this study, we revealed the neuroprotective effect of GSSE on midbrain dopaminergic neurons both in vitro and in vivo. We used the neurotoxin 6-hydroxydopamine (6-OHDA), which induces oxidative damage and mimics the degeneration of dopaminergic neurons observed in Parkinson's disease. We found that GSSE was effective in protecting dopamine neurons from 6-OHDA toxicity by reducing apoptosis, the level of reactive oxygen species (ROS) and inflammation. Furthermore, we found that GSSE treatment efficiently protected against neuronal loss and improved motor function in an in vivo 6-OHDA model of Parkinson's disease (PD). Altogether, our results show that GSSE acts at multiple levels to protect dopamine neurons from degeneration in a model of PD. |
| Databáze: | OpenAIRE |
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