Adenomas in Patients with Inflammatory Bowel Disease Are Associated with an Increased Risk of Advanced Neoplasia
| Autor: | Schaik, F.D.M. van, Mooiweer, E., Have, M. van der, Belderbos, T.D.G., Kate, F.J.W. ten, Offerhaus, G.J.A., Schipper, M.E.I., Dijkstra, G., Pierik, M., Stokkers, P.C.F., Ponsioen, C., Jong, D.J. de, Hommes, D.W., Bodegraven, A.A. van, Siersema, P.D., Oijen, M.G.H. van, Oldenburg, B., Dutch Initiative Crohn Colitis ICC |
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| Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM - R2 - Gut-liver homeostasis, Gastroenterology and hepatology, CCA - Innovative therapy, Other departments, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Oncology, Public Health, Gastroenterology & Hepatology, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Groningen Institute for Organ Transplantation (GIOT) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
POLYPS endocrine system diseases Colorectal cancer medicine.medical_treatment Kaplan-Meier Estimate Inflammatory bowel disease Gastroenterology COLORECTAL-CANCER Immunology and Allergy POLYPECTOMY Middle Aged adenoma Female Colorectal Neoplasms Adult Risk DYSPLASTIC LESIONS medicine.medical_specialty Adenoma CARCINOMA CHRONIC ULCERATIVE-COLITIS colorectal cancer Molecular gastro-enterology and hepatology Pathogenesis and modulation of inflammation [IGMD 2] digestive system dysplasia inflammatory bowel disease Internal medicine SURVEILLANCE Carcinoma medicine Humans Molecular gastro-enterology and hepatology [IGMD 2] Proportional Hazards Models Retrospective Studies Proportional hazards model business.industry Retrospective cohort study ENDOSCOPIC RESECTION medicine.disease Inflammatory Bowel Diseases Polypectomy digestive system diseases stomatognathic diseases Dysplasia ADEQUATE TREATMENT Neoplasm Grading business FOLLOW-UP Precancerous Conditions Follow-Up Studies |
| Zdroj: | Inflammatory Bowel Diseases, 19(2), 342-349. LIPPINCOTT WILLIAMS & WILKINS Inflammatory Bowel Diseases, 19(2), 342-349 Inflammatory Bowel Diseases, 19(2), 342-349. John Wiley and Sons Inc. Inflammatory bowel diseases, 19(2), 342-349. John Wiley and Sons Inc. van Schaik, F D M, Mooiweer, E, ten Have, M, Belderbos, T D G, Ten Kate, F J W, Offerhaus, G J A, Schipper, M E I, Dijkstra, G, Pierik, M, Stokkers, P C F, Ponsioen, C, de Jong, D J, Hommes, D W, van Bodegraven, A A, Siersema, P D, van Oijen, M G H & Oldenburg, B 2013, ' Adenomas in Patients with Inflammatory Bowel Disease Are Associated with an Increased Risk of Advanced Neoplasia ', Inflammatory Bowel Diseases, vol. 19, no. 2, pp. 342-349 . https://doi.org/10.1097/MIB.0b013e318286f771 Inflammatory Bowel Diseases, 19, 342-349 Inflammatory Bowel Diseases, 19, 2, pp. 342-349 Inflammatory Bowel Diseases, 19(2), 342-349. Oxford University Press |
| ISSN: | 1078-0998 |
| DOI: | 10.1097/MIB.0b013e318286f771 |
| Popis: | Background: It is still unclear whether inflammatory bowel disease (IBD) patients with adenomas have a higher risk of developing high-grade dysplasia (HGD) or colorectal cancer (CRC) than non-IBD patients with sporadic adenomas. We compared the risk of advanced neoplasia (AN, defined as HGD or CRC) in IBD patients with adenomas to IBD patients without adenomas and patients without IBD with adenomas.Methods: IBD patients with a histological adenoma diagnosis (IBD + adenoma), age-matched IBD patients without adenoma (IBD-nonadenoma), and adenoma patients without IBD (nonIBD + adenoma) were enrolled in this study. Medical charts were reviewed for adenoma characteristics and development of AN. The endoscopic appearance of the adenomas was characterized as typical (solitary sessile or pedunculated) or atypical (all other descriptions).Results: A total of 110 IBD + adenoma patients, 123 IBD-nonadenoma patients, and 179 nonIBD + adenoma patients were included. Mean duration of follow-up was 88 months (SD +/- 41). The 5-year cumulative risks of AN were 11%, 3%, and 5% in IBD + adenoma, IBD-nonadenoma, and nonIBD + adenoma patients, respectively (P Conclusions: IBD patients with a histological diagnosis of adenoma have a higher risk of developing AN than adenoma patients without IBD and IBD patients without adenomas. The presence of atypical adenomas in particular was associated with this increased risk, although patients with typical adenomas were found to carry an additional risk as well. (Inflamm Bowel Dis 2013; 19: 342-349) |
| Databáze: | OpenAIRE |
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