Carbohydrate formation from various precursors in neonatal rat liver
| Autor: | Susan W. Eaton, Deryck G. Walker, Richard G. Vernon |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Glycerol
Threonine History medicine.medical_specialty Oxaloacetates In Vitro Techniques Biology Education chemistry.chemical_compound Internal medicine Serine medicine Animals Citrate synthase Hydro-Lyases Alanine chemistry.chemical_classification Carbon Isotopes Glycogen Gluconeogenesis Caseins Articles Rats Computer Science Applications Amino acid Glucose Endocrinology Animals Newborn Liver chemistry Biochemistry Dehydratase Lactates biology.protein |
| Zdroj: | Biochemical Journal. 110:725-731 |
| ISSN: | 0306-3283 |
| DOI: | 10.1042/bj1100725 |
| Popis: | 1. Measurements of the net synthesis of glucose plus glycogen from various precursors in slices of glycogen-depleted livers from rats at various stages of development indicated an increase in the gluconeogenic capacity after birth with l-lactate, oxaloacetate, a casein hydrolysate, l-serine, l-threonine, l-alanine and glycerol as substrates. 2. The highest rates of incorporation of 14C-labelled precursors into glucose plus glycogen in slices of normal livers of rats of various ages were observed in such tissue preparations from neonatal animals for an amino acid mixture, l-alanine, l-serine and l-threonine. 3. The activities of rat hepatic l-serine dehydratase and l-threonine dehydratase increase rapidly after birth and show maxima about 20 days later. 4. The results provide further evidence of the increased capacity for hepatic gluconeogenesis in the neonatal period and suggest various sites of regulation of the process. |
| Databáze: | OpenAIRE |
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