Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia–pyometra
| Autor: | Nilgün Gültiken, Gul Fatma Yarim, Murat Yarim, Elvan Anadol, Murat Findik, Mahmut Sözmen |
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| Rok vydání: | 2021 |
| Předmět: |
040301 veterinary sciences
Uterus Ovary Enteroendocrine cell Endometrium 030308 mycology & parasitology 0403 veterinary science Andrology 03 medical and health sciences Dogs Insulin-Like Growth Factor II Pyometra medicine Animals Dog Diseases Cervix 0303 health sciences General Veterinary biology business.industry 04 agricultural and veterinary sciences Cystic Endometrial Hyperplasia medicine.disease medicine.anatomical_structure Insulin-like growth factor 2 Endometrial Hyperplasia biology.protein Female business |
| Zdroj: | Acta Veterinaria Hungarica. 69:73-79 |
| ISSN: | 1588-2705 0236-6290 |
| Popis: | The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)–pyometra complex. Group 1 (n = 10) included bitches with open cervix pyometra, while Group 2 (n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. IGF-2 immunopositivity was observed in the endometrial glandular epithelium in both groups. Additionally, interstitial fibroblasts and macrophages in the endometrium were also positive in Group 1. The concentration of plasma IGF-2 was higher in Group 1 than in Group 2 (P < 0.05). The concentration was positively correlated with IGF-2 expression in the endometrial glands (r = 0.926; P < 0.001) in Group 1. However, a negative correlation was present between plasma IGF-2 concentration and IGF-2 expression in the interstitial endocrine cells of the ovary in Group 1 (r = −0.652; P < 0.05). The results suggest that IGF-2 plays an important role during the inflammatory process occurring in bitches with CEH–pyometra complex as well as in the endometrium of healthy bitches in dioestrus. |
| Databáze: | OpenAIRE |
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