Gender differences in the pharmacokinetics of DA-6034, a derivative of flavonoids, in rats
| Autor: | Moohi Yoo, Jong W. Kwon, Soo K. Bae, Si H. Yang, Myung Gyoon Lee |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Pharmaceutical Science Administration Oral Urine Pharmacology Rats Sprague-Dawley Sex Factors Pharmacokinetics Oral administration Internal medicine Male rats medicine Animals Pharmacology (medical) Intravenous dose Flavonoids Time zero business.industry General Medicine Rats Endocrinology Plasma concentration Injections Intravenous Female business |
| Zdroj: | Biopharmaceuticsdrug disposition. 27(1) |
| ISSN: | 0142-2782 |
| Popis: | Gender differences in the pharmacokinetics of DA-6034 were evaluated after intravenous and oral administration at a dose of 50 mg/kg to male and female Sprague–Dawley rats. After intravenous administration to male rats, although the total area under the plasma concentration–time curve from time zero to time infinity of DA-6034 was not significantly different between male and female rats, the plasma concentrations of DA-6034 were lower from 30 min to 480 min, the mean residence time was significantly shorter (6.28 versus 12.2 min), the percentage of intravenous dose of DA-6034 excreted in 24h urine as unchanged drug was significantly greater (14.4% versus 10.5% of intravenous dose). After oral administration, the pharmacokinetic parameters of DA-6034 were not significantly different between male and female rats. Copyright © 2005 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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