Pathway-based genome-wide association analysis identified the importance of EphrinA–EphR pathway for femoral neck bone geometry
| Autor: | Feng Zhang, Feng Pan, Dong Hai Xiong, Qi Zhou, Hong-Wen Deng, Yan-Fang Guo, Yuan Chen |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Candidate gene Histology Genotype Physiology Endocrinology Diabetes and Metabolism Genome-wide association study Biology Bioinformatics Article DHRS1 EPH receptor A5 EPH receptor A3 medicine Humans Aged Femoral neck Genetic association Genetics Femur Neck Middle Aged EPH receptor A1 medicine.anatomical_structure Female Ephrins Genome-Wide Association Study Signal Transduction |
| Zdroj: | Bone. 46:129-136 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2009.09.025 |
| Popis: | Femoral neck (FN) bone geometry is an important predictor of bone strength with high heritability. Previous studies have revealed certain candidate genes for FN bone geometry. However, the majority of the underlying genetic factors remain to be discovered. In this study, pathway-based genome-wide association analysis was performed to explore the joint effects of genes within biological pathways on FN bone geometry variations in a cohort of 1,000 unrelated U.S. whites. Nominal significant associations (nominal p value < 0.05) were observed between 76 pathways and a key FN bone geometry variable - section modulus (Z), biomechanically indicative of bone strength subject to bending. Among them, EphrinA-EphR pathway was most significantly associated with FN Z even after multiple testing adjustments (pFWER value = 0.035). The association of EphrinA-EphR pathway with FN Z was also observed in an independent sample from Framingham Osteoporosis Study. Overall, these results suggest the significant genetic contribution of EphrinA-EphR pathway to femoral neck bone geometry. |
| Databáze: | OpenAIRE |
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