An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD

Autor: Barbara Franke, Jan K. Buitelaar, A. Marije Boonstra, J. J. Sandra Kooij, Joseph A. Sergeant, Jaap Oosterlaan, J.G.A.M. Angelien Heister
Přispěvatelé: Other departments, Clinical Neuropsychology
Rok vydání: 2008
Předmět:
Adult
Male
Candidate gene
Genetics and epigenetic pathways of disease [NCMLS 6]
Biology
Neuroinformatics [DCN 3]
Mental health [NCEBP 9]
behavioral disciplines and activities
Genetic determinism
Genomic disorders and inherited multi-system disorders [IGMD 3]
Cellular and Molecular Neuroscience
Cognition
Cognitive neurosciences [UMCN 3.2]
Polymorphism (computer science)
Genotype
mental disorders
medicine
Perception and Action [DCN 1]
Attention deficit hyperactivity disorder
Humans
Genetics (clinical)
DNA Primers
Genetics
Polymorphism
Genetic
Base Sequence
Middle Aged
medicine.disease
Psychiatry and Mental health
Variable number tandem repeat
Genetic defects of metabolism [UMCN 5.1]
Attention Deficit Disorder with Hyperactivity
Endophenotype
Female
Neurocognitive
Functional Neurogenomics [DCN 2]
Zdroj: American journal of medical genetics. Part B, Neuropsychiatric genetics, 147B(3), 397-402. Wiley-Liss Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(3), 397-402. Wiley-Liss Inc.
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147, 3, pp. 397-402
Boonstra, A M, Kooij, S J J, Buitelaar, J, Oosterlaan, J, Sergeant, J A, Heister, J G A M & Franke, B 2008, ' An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD ', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 147B, no. 3, pp. 397-402 . https://doi.org/10.1002/ajmg.b.30595
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147, 397-402
ISSN: 1552-4841
Popis: Contains fulltext : 69754.pdf (Publisher’s version ) (Closed access) Since neurocognitive performance is a possible endophenotype for Attention Deficit Hyperactivity Disorder (ADHD) we explored the relationship between four genetic polymorphisms and neurocognitive performance in adults with ADHD. We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 48 base pair (bp) repeat, DRD4 120 bp duplicated repeat, SLC6A3 (DAT1) 40 bp variable number of tandem repeats (VNTR), and COMT Val158Met). We then sub-grouped the sample for each polymorphism by genotype or by the presence of the (putative) ADHD risk allele and compared the performance of the subgroups on a large battery of neurocognitive tests. The COMT Val158Met polymorphism was related to differences in IQ and reaction time, both of the DRD4 polymorphisms (48 bp repeat and 120 bp duplication) showed an association with verbal memory skills, and the SLC6A3 40 bp VNTR polymorphism could be linked to differences in inhibition. Interestingly, the presence of the risk alleles in DRD4 and SLC6A3 was related to better cognitive performance. Our findings contribute to an improved understanding of the functional implications of risk genes for ADHD.
Databáze: OpenAIRE
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