Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites

Autor: Vincent A. Mukkada, Paul Menard-Katcher, Alicia Hurnton, Gary W. Falk, Guang Yu Yang, Wendy Book, Heather Foote, Deirdre Burke, Katherine Thompson, Eileen King, Mary Jo Strobel, Jonathan Kuhl, Ikuo Hirano, Barry K. Wershil, Denise Mack, Jeanie Bailey, Ellyn Kodroff, Allison Dubner, Melissa K. Mingler, Cathy Reidy, Kelley E. Capocelli, Susan Moist, Zhaoxing Pan, John Leung, Amanda B. Muir, Heidi Poppendeck, Maureen DeMarschall, Glenn T. Furuta, Jessi Lipscomb, Megan Lewis, John A. Besse, Melissa Scott, Margaret H. Collins, Dan Atkins, Amanda K. Rudman-Spergel, Sarah McGee, Qin Sun, Michael D. Eby, Evan S. Dellon, Marc E. Rothenberg, Sandeep K. Gupta, Kathleen Sable, Shaobo Guan, Joshua B. Wechsler, Seema S. Aceves, Nirmala Gonsalves, Christina L Carpenter, Kendra Kocher, Shay Kyle, Jeffrey P. Krischer, J. Pablo Abonia, Jonathan M. Spergel, Jacquelyn Covington, Peter A Bonis, Ashley Arrington, Ranjan Dohil, Philip E. Putnam
Rok vydání: 2018
Předmět:
Parents
Male
Allergy
pediatric QOL EoE module
Disease
Eosinophil
eosinophilic esophagitis
0302 clinical medicine
Quality of life
Interquartile range
Surveys and Questionnaires
Eosinophilic
Immunology and Allergy
Child
pediatric eosinophilic esophagitis symptom score
eosinophilic oesophagitis
Pediatric
patient-reported outcomes
Child
Preschool
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Patient-reported outcome
medicine.medical_specialty
Adolescent
Clinical Trials and Supportive Activities
Immunology
Food Allergies
Consortium of Eosinophilic Gastrointestinal Disease Researchers
Article
03 medical and health sciences
Clinical Research
version 2
Internal medicine
medicine
Humans
Patient Reported Outcome Measures
Preschool
Eosinophilic esophagitis
business.industry
Eosinophilic Esophagitis
medicine.disease
Clinical trial
quality of life
Quality of Life
GERD
symptoms
Self Report
Digestive Diseases
business
Zdroj: The Journal of allergy and clinical immunology, vol 142, iss 1
ISSN: 0091-6749
Popis: BACKGROUND: Patient-reported outcome (PRO) metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. OBJECTIVE: We sought to understand 1) the potential of care-giver report to predict patient self-reported symptoms and 2) the correlation of PRO domains with histology. METHODS: Subjects with EoE (n=310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) using the Pediatric Eosinophilic Esophagitis Symptom Score version 2 (PEESSv2.0), Pediatric QOL EoE module (PedsQL-EoE) and biopsies were analyzed using the EoE histology scoring system (EoEHSS). RESULTS: PEESSv2.0 parent and child report aligned across all domains (r=0.68-0.73, p
Databáze: OpenAIRE
Externí odkaz: