A clinicopathological study of adenocarcinoma in situ of the cervix. The influence of cervical HPV infection and other factors, and the role of conservative surgery
| Autor: | Bruce G. Ward, James L. Nicklin, H. Samartunga, N. C. Cox, J. R. Bell, R. G. Wright |
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| Rok vydání: | 1991 |
| Předmět: |
Oncology
medicine.medical_treatment Biopsy Uterine Cervical Neoplasms Uterine Cervical Diseases Risk Factors Marriage Papillomaviridae media_common biology Incidence (epidemiology) Incidence Smoking HPV infection Age Factors Obstetrics and Gynecology General Medicine Middle Aged Acis Parity medicine.anatomical_structure Marital status Female Queensland medicine.symptom DNA Probes Carcinoma in Situ Adult medicine.medical_specialty media_common.quotation_subject education Fertility Adenocarcinoma Hysterectomy Lesion Internal medicine medicine Humans Hospitals Teaching Cervix Gynecology business.industry Adenocarcinoma in situ medicine.disease biology.organism_classification Surgery Tumor Virus Infections business Follow-Up Studies |
| Zdroj: | The AustralianNew Zealand journal of obstetricsgynaecology. 31(2) |
| ISSN: | 0004-8666 |
| Popis: | Adenocarcinoma in situ (ACIS) of the uterine cervix is an increasingly recognized disease. Thirty-seven cases were reviewed to determine the effect of HPV, marital status, parity, smoking habit and age on the topography and behaviour of this lesion. Using a commercial probe, 25% of 28 lesions tested were positive for HPV 16/18. The presence of HPV and a history of smoking appeared to exert no significant influence upon the topography and behaviour of ACIS. Nulliparity and a history of never being married was associated with a significant reduction in the incidence of coexisting CIN lesions. Age less than 36 years was associated with a significant reduction in the proximal linear extent of ACIS. While hysterectomy is probably the definitive treatment for ACIS of the cervix, there is an important place for conservative management by conization alone. Patients younger than 36 years are most likely to be desirous of retained fertility and appear to have the lesions most amenable to conservative surgery. |
| Databáze: | OpenAIRE |
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