Cytokine Profile in Patients With Maturity-onset Diabetes of the Young (MODY)
| Autor: | AYCA DIREN, DENIZ KANCA DEMIRCI, NURDAN GUL, BURCIN KARACANLI, AYKUT BAYKUT, YILDIZ TUTUNCU, OGUZ OZTURK, ILHAN SATMAN, HULYA YILMAZ-AYDOGAN |
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| Přispěvatelé: | Tütüncü, Yıldız (ORCID 0000-0002-3905-6429 & YÖK ID 239430), Diren, A., Demirci, D.K., Gül, N., Karacanlı, B., Baykut, A., Öztürk, O., Satman, I., Yılmaz Aydoğan, H., Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine |
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Cancer Research Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-17 Pro-inflammatory cytokines Hs-CRP HbA1c MODY MODY3 Diabetes Interleukin-23 Research and experimental medicine General Biochemistry Genetics and Molecular Biology C-Reactive Protein Diabetes Mellitus Type 2 Diabetes Mellitus Cytokines Humans Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 |
| Popis: | Background/aim: high-sensitivity C-reactive protein (hs-CRP) is used in the differential diagnosis of maturity-onset diabetes of the young (MODY)-3, but other inflammatory markers have not been investigated in MODY patients. We aimed to compare the serum levels of anti-inflammatory and proinflammatory cytokines between MODY patients and healthy subjects and show the inflammatory features in MODY subtypes. Patients and methods: thirty patients with clinically suspected MODY and 34 healthy controls were included in this study. Next -generation sequencing (NGS) was used for the molecular diagnosis of MODY subtypes. Serum levels of cytokines were measured using a multiplexed cytokine assay and hs-CRP concentration was determined by the immunoturbidimetric assay. Results: the hs-CRP levels were higher in both NGS-confirmed (MODY, n=17) (p=0.009) and NGS-unconfirmed (non-MODY, n=13) patients (p This study was supported by the Scientific Research Fund of Istanbul University within the scope of the project entitled “Investigation of Inflammatory Cytokine Profile in Maturity-Onset Diabetes of the Young (MODY)” (Project no. TSA-2017-25335). The Authors thank their patients and healthy control subjects who participated in the study |
| Databáze: | OpenAIRE |
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