Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study
| Autor: | David M. Herrington, Philip B. Mellen, Lynne E. Wagenknecht, Janet A. Tooze, Mara Z. Vitolins, Angela D. Liese |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Carotid Artery Diseases Dietary Fiber Male medicine.medical_specialty Carotid Artery Common Medicine (miscellaneous) Observation Gastroenterology Insulin resistance medicine.artery Internal medicine Surveys and Questionnaires medicine Humans cardiovascular diseases Common carotid artery Ultrasonography Interventional Aged Nutrition and Dietetics business.industry Vascular disease Confounding Confounding Factors Epidemiologic Middle Aged medicine.disease Atherosclerosis Diet Endocrinology medicine.anatomical_structure Cohort cardiovascular system Disease Progression Female Internal carotid artery business Edible Grain Tunica Intima Carotid Artery Internal Cohort study Artery |
| Zdroj: | The American journal of clinical nutrition. 85(6) |
| ISSN: | 0002-9165 |
| Popis: | Background Whole-grain intake has been shown to be inversely associated with cardiovascular events, but an association with atherosclerosis is less well established. Objective We sought to evaluate the association of whole-grain intake with carotid intimal medial thickness (IMT) and IMT progression in a multiethnic cohort. Design This study evaluated 1178 participants in the Insulin Resistance Atherosclerosis Study. Baseline whole-grain intake was estimated on the basis of intake of dark breads, cooked cereals, and high-fiber cereals assessed with a validated food-frequency questionnaire. Bilateral carotid IMT was evaluated ultrasonographically, yielding 16 IMT measures at baseline and year 5. Multivariate models evaluated the independent association of whole-grain intake with common carotid artery (CCA) and internal carotid artery (ICA) IMT and IMT progression. Results The cohort had a mean (+/-SD) age of 55.2 +/- 8.4 y and was 56% female. The baseline median whole-grain intake was 0.79 servings/d. Whole-grain intake was inversely associated with CCA IMT (beta +/- SE: -0.043 +/- 0.013, P = 0.005) and IMT progression (beta +/- SE: -0.019 +/- 0.011, P = 0.09) in models adjusted for demographics, energy intake, energy expenditure, cardiovascular disease risk factors, and medication use. This association was less significant for ICA IMT (beta +/- SE: -0.049 +/- 0.023, P = 0.05) and not significant for ICA IMT progression (beta +/- SE: -0.013 +/- 0.014, P = 0.35). The relation between whole-grain intake and CCA IMT remained significant after adjustment for mediating pathways (lipids, adiposity, and insulin resistance), nutrient constituents, and a principal components-derived healthy dietary pattern. Conclusions Whole-grain intake is inversely associated with CCA IMT, and this relation is not attributable to individual risk intermediates, single nutrient constituents, or larger dietary patterns. |
| Databáze: | OpenAIRE |
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