Design, synthesis, biological evaluation, and in silico studies of 2-aminobenzothiazole derivatives as potent PI3Kα inhibitors
| Autor: | Kashif Haider, Kamal Ahmad, Abul Kalam Najmi, Subham Das, Alex Joseph, M. Shahar Yar |
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| Rok vydání: | 2022 |
| Předmět: |
Molecular Structure
Pharmaceutical Science Antineoplastic Agents Apoptosis Molecular Docking Simulation Phosphatidylinositol 3-Kinases Structure-Activity Relationship Cell Line Tumor Drug Design Drug Discovery Humans Myeloid Cell Leukemia Sequence 1 Protein Drug Screening Assays Antitumor Proto-Oncogene Proteins c-akt Cell Proliferation |
| Zdroj: | Archiv der PharmazieREFERENCES. 355(10) |
| ISSN: | 1521-4184 |
| Popis: | A new series of 2-aminobenzothiazole derivatives was designed, synthesized and evaluated for their anticancer activity against the MCF7, MDAMB-231, and HepG2 cancer cell lines. All synthesized derivatives (8a-8n) demonstrated moderate to high anticancer activity against the tested cell lines. As the most potent compound in the series, compound 8i displayed excellent inhibitory potency with an IC |
| Databáze: | OpenAIRE |
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