Association of Single-Nucleotide Polymorphisms of CD44 Gene with Susceptibility to Breast Cancer in Chinese Women
| Autor: | Shenghua Pan, Xiao Lin, Xiaojing You, Xuezhen Cao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Breast Neoplasms Triple Negative Breast Neoplasms Single-nucleotide polymorphism Polymorphism Single Nucleotide Linkage Disequilibrium 03 medical and health sciences 0302 clinical medicine Breast cancer Asian People Gene Frequency Risk Factors Lab/In Vitro Research Internal medicine Genotype medicine Humans SNP Genetic Predisposition to Disease 030212 general & internal medicine Allele Genetic Association Studies Aged business.industry Haplotype General Medicine Middle Aged medicine.disease Antigens CD44 Hyaluronan Receptors Haplotypes Genetic Loci Risk factors for breast cancer Case-Control Studies 030220 oncology & carcinogenesis Female Receptors Progesterone business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.907422 |
| Popis: | BACKGROUND This study aimed to evaluate the association of CD44 gene single-nucleotide polymorphisms with susceptibility to breast cancer. MATERIAL AND METHODS This case-control study included 242 breast cancer patients and 252 normal people without disease. The single-nucleotide polymorphisms of the CD44 gene in the 2 groups were genotyped by PCR-LDR method. The OR and its 95% CI was calculated by chi-square test and logistic regression analysis. The construction of haplotypes and their interaction analysis with relevant factors were carried out by SHEsis and SNPStats online. RESULTS The genotype distribution of CC and CT, CC and CC+CT, and CC+CT and TT in rs13347 showed a significant difference between cases and controls, and the difference in distribution of alleles C and T was statistically significant. The genotype and alleles distribution of rs4756195 and rs8193 showed no statistically significant difference (P>0.05). The haplotypes distribution of CAC, CGT, TAC, and TGT showed a significant difference between the 2 groups (P |
| Databáze: | OpenAIRE |
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