A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei
| Autor: | Wei Wang, De-An Guo, Ning-bo Gong, Yang Lu, Siwang Yu, Min Ye, Xiang-hui He, Ikhlas A. Khan, Yong-hong Liang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Dryopteris crassirhizoma Molecular Structure Stereochemistry General Medicine Biology biology.organism_classification Antineoplastic Agents Phytogenic Triterpenes Rhizome Drynaria fortunei HeLa Triterpenoid Polypodiaceae Cell Line Tumor Neoplasms Hepg2 cells Drug Discovery Animals Humans Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Fitoterapia. 81:988-991 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2010.06.013 |
| Popis: | Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 μM, 1.08 μM and 2.45 μM, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect