Analysis of Environmental Chemical Mixtures and Non-Hodgkin Lymphoma Risk in the NCI-SEER NHL Study
| Autor: | Anneclaire J. De Roos, Patricia Hartge, Mary H. Ward, Chris Gennings, Jenna Czarnota, James R. Cerhan, Joanne S. Colt, David C. Wheeler, Richard K. Severson |
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| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Health Toxicology and Mutagenesis macromolecular substances 010501 environmental sciences 01 natural sciences 03 medical and health sciences Young Adult 0302 clinical medicine Chemical mixtures Environmental risk immune system diseases hemic and lymphatic diseases Internal medicine Floors and Floorcoverings Seer program medicine Humans 030212 general & internal medicine Young adult neoplasms 0105 earth and related environmental sciences Aged Air Pollutants business.industry Lymphoma Non-Hodgkin Research Public Health Environmental and Occupational Health Case-control study Dust Environmental exposure Environmental Exposure Middle Aged medicine.disease United States 3. Good health Lymphoma Air Pollution Indoor Case-Control Studies Immunology Hodgkin lymphoma Regression Analysis Female business SEER Program |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 |
| Popis: | Background There are several suspected environmental risk factors for non-Hodgkin lymphoma (NHL). The associations between NHL and environmental chemical exposures have typically been evaluated for individual chemicals (i.e., one-by-one). Objectives We determined the association between a mixture of 27 correlated chemicals measured in house dust and NHL risk. Methods We conducted a population-based case–control study of NHL in four National Cancer Institute–Surveillance, Epidemiology, and End Results centers—Detroit, Michigan; Iowa; Los Angeles County, California; and Seattle, Washington—from 1998 to 2000. We used weighted quantile sum (WQS) regression to model the association of a mixture of chemicals and risk of NHL. The WQS index was a sum of weighted quartiles for 5 polychlorinated biphenyls (PCBs), 7 polycyclic aromatic hydrocarbons (PAHs), and 15 pesticides. We estimated chemical mixture weights and effects for study sites combined and for each site individually, and also for histologic subtypes of NHL. Results The WQS index was statistically significantly associated with NHL overall [odds ratio (OR) = 1.30; 95% CI: 1.08, 1.56; p = 0.006; for one quartile increase] and in the study sites of Detroit (OR = 1.71; 95% CI: 1.02, 2.92; p = 0.045), Los Angeles (OR = 1.44; 95% CI: 1.00, 2.08; p = 0.049), and Iowa (OR = 1.76; 95% CI: 1.23, 2.53; p = 0.002). The index was marginally statistically significant in Seattle (OR = 1.39; 95% CI: 0.97, 1.99; p = 0.071). The most highly weighted chemicals for predicting risk overall were PCB congener 180 and propoxur. Highly weighted chemicals varied by study site; PCBs were more highly weighted in Detroit, and pesticides were more highly weighted in Iowa. Conclusions An index of chemical mixtures was significantly associated with NHL. Our results show the importance of evaluating chemical mixtures when studying cancer risk. Citation Czarnota J, Gennings C, Colt JS, De Roos AJ, Cerhan JR, Severson RK, Hartge P, Ward MH, Wheeler DC. 2015. Analysis of environmental chemical mixtures and non-Hodgkin lymphoma risk in the NCI-SEER NHL Study. Environ Health Perspect 123:965–970; http://dx.doi.org/10.1289/ehp.1408630 |
| Databáze: | OpenAIRE |
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